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| 18.11.2005 | 20:00 | Stormvogels Telstar | - | Go Ahead Eagles | 1:0 (0:0) | |
| 20:00 | TOP Oss | - | De Graafschap | 1:0 (1:0) | ||
| 20:00 | Fortuna Sittard | - | FC Den Bosch | 1:2 (1:1) | ||
| 20:00 | FC Zwolle | - | MVV Maastricht | 4:1 (2:0) | ||
| 20:00 | SC Cambuur | - | FC Eindhoven | 1:0 (0:0) | ||
| 20:00 | FC Emmen | - | BV Veendam | 2:1 (1:1) | ||
| 20:00 | VVV-Venlo | - | SBV Excelsior | 1:0 (0:0) | ||
| 20:00 | FC Omniworld | - | FC Volendam | 1:1 (1:1) | ||
| 20:00 | Helmond Sport | - | FC Dordrecht | 1:0 (1:0) | ||
| 20:00 | HFC Haarlem | - | AGOVV | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VVV-Venlo | 18 | 12 | 4 | 2 | 30:9 | 21 | 40 |
| 2 |
|
FC Volendam | 18 | 11 | 4 | 3 | 32:16 | 16 | 37 |
| 3 |
|
SBV Excelsior | 18 | 11 | 3 | 4 | 32:12 | 20 | 36 |
| 4 |
|
FC Emmen | 18 | 11 | 2 | 5 | 37:21 | 16 | 35 |
| 5 |
|
FC Zwolle | 18 | 10 | 4 | 4 | 33:19 | 14 | 34 |
| 6 |
|
FC Den Bosch | 18 | 9 | 5 | 4 | 33:24 | 9 | 32 |
| 7 |
|
Helmond Sport | 18 | 9 | 3 | 6 | 27:28 | -1 | 30 |
| 8 |
|
MVV Maastricht | 18 | 7 | 6 | 5 | 27:23 | 4 | 27 |
| 9 |
|
BV Veendam | 18 | 7 | 4 | 7 | 23:21 | 2 | 25 |
|
De Graafschap | 18 | 7 | 4 | 7 | 23:21 | 2 | 25 | |
| 11 |
|
FC Dordrecht | 18 | 6 | 6 | 6 | 22:20 | 2 | 24 |
| 12 |
|
Go Ahead Eagles | 18 | 5 | 6 | 7 | 23:28 | -5 | 21 |
| 13 |
|
TOP Oss | 18 | 5 | 6 | 7 | 21:29 | -8 | 21 |
| 14 |
|
AGOVV | 18 | 6 | 2 | 10 | 32:33 | -1 | 20 |
| 15 |
|
Stormvogels Telstar | 18 | 4 | 7 | 7 | 17:26 | -9 | 19 |
| 16 |
|
HFC Haarlem | 18 | 5 | 3 | 10 | 18:37 | -19 | 18 |
| 17 |
|
FC Eindhoven | 18 | 4 | 4 | 10 | 25:30 | -5 | 16 |
| 18 |
|
SC Cambuur | 18 | 3 | 8 | 7 | 18:25 | -7 | 14 |
| 19 |
|
FC Omniworld | 18 | 3 | 2 | 13 | 21:47 | -26 | 11 |
| 20 |
|
Fortuna Sittard | 18 | 1 | 5 | 12 | 17:42 | -25 | 8 |
| Promotie |
