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| 01.04.2011 | 20:00 | BV Veendam | - | SC Cambuur | 1:1 (0:1) | |
| 20:00 | Almere City FC | - | FC Eindhoven | 3:0 (2:0) | ||
| 20:00 | Fortuna Sittard | - | MVV Maastricht | 0:0 (0:0) | ||
| 20:00 | Telstar | - | FC Zwolle | 0:0 (0:0) | ||
| 20:00 | AGOVV | - | FC Volendam | 2:1 (1:0) | ||
| 20:00 | FC Den Bosch | - | FC Dordrecht | 0:0 (0:0) | ||
| 20:00 | Helmond Sport | - | FC Emmen | 2:2 (1:1) | ||
| 20:45 | Sparta Rotterdam | - | RKC Waalwijk | 3:4 (2:2) | ||
| 04.04.2011 | 20:45 | Go Ahead Eagles | - | RBC Roosendaal | 2:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Zwolle | 29 | 19 | 7 | 3 | 63:19 | 44 | 63 |
| 2 |
|
RKC Waalwijk | 29 | 18 | 6 | 5 | 69:38 | 31 | 60 |
| 3 |
|
Helmond Sport | 29 | 15 | 6 | 8 | 54:37 | 17 | 51 |
| 4 |
|
BV Veendam | 29 | 14 | 10 | 5 | 48:36 | 12 | 48 |
| 5 |
|
SC Cambuur | 29 | 13 | 7 | 9 | 53:41 | 12 | 43 |
| 6 |
|
Go Ahead Eagles | 29 | 11 | 8 | 10 | 50:37 | 13 | 41 |
| 7 |
|
FC Volendam | 29 | 11 | 8 | 10 | 43:42 | 1 | 41 |
| 8 |
|
FC Den Bosch | 29 | 8 | 12 | 9 | 47:44 | 3 | 36 |
| 9 |
|
MVV Maastricht | 29 | 12 | 8 | 9 | 39:41 | -2 | 36 |
| 10 |
|
FC Eindhoven | 29 | 9 | 9 | 11 | 35:39 | -4 | 36 |
| 11 |
|
Sparta Rotterdam | 29 | 9 | 7 | 13 | 64:60 | 4 | 34 |
| 12 |
|
FC Dordrecht | 29 | 10 | 8 | 11 | 42:48 | -6 | 34 |
| 13 |
|
FC Emmen | 29 | 8 | 9 | 12 | 44:53 | -9 | 33 |
| 14 |
|
Telstar | 29 | 7 | 8 | 14 | 35:44 | -9 | 29 |
| 15 |
|
AGOVV | 29 | 11 | 5 | 13 | 47:65 | -18 | 29 |
| 16 |
|
Fortuna Sittard | 29 | 6 | 6 | 17 | 37:64 | -27 | 22 |
| 17 |
|
RBC Roosendaal | 29 | 6 | 6 | 17 | 32:52 | -20 | 21 |
| 18 |
|
Almere City FC | 29 | 7 | 4 | 18 | 38:80 | -42 | 19 |
| Promotie | |
| Play-offs | |
| Play-offs | |
| Degradatie |
