| 1. Ronde | 08.01.2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
| 2. Ronde | 15.01.2022 | Club León [] | - | UANL Tigres [] | 1:3 | ||||
| 5. Ronde | 05.02.2022 | CF Monterrey [] | - | Club León [] | 1:0 | ||||
| 6. Ronde | 12.02.2022 | Club León [] | - | Atlético San Luis [] | 1:0 | ||||
| 7. Ronde | 18.02.2022 | Club León [] | - | Santos Laguna [] | 2:2 | ||||
| 8. Ronde | 26.02.2022 | Atlas Guadalajara [] | - | Club León [] | 4:1 | ||||
| 9. Ronde | 05.03.2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
| 10. Ronde | 12.03.2022 | UANL Tigres [] | - | Club León [] | 1:1 | ||||
| 12. Ronde | 26.03.2022 | Club León [] | - | Deportivo Guadalajara [] | 1:4 |
Mexico