| 1. Ronde | 18.07.2021 | River Plate | - | Colón de Santa Fe | 1:2 |  |
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| 5. Ronde | 08.08.2021 | Godoy Cruz | - | River Plate | 2:1 | ||||
| 6. Ronde | 14.08.2021 | River Plate | - | Vélez Sarsfield | 2:0 | ||||
| 7. Ronde | 23.08.2021 | Gimnasia de La Plata | - | River Plate | 1:1 | ||||
| 8. Ronde | 27.08.2021 | River Plate | - | Aldosivi | 2:0 | |
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| 9. Ronde | 31.08.2021 | Sarmiento de Junín | - | River Plate | 1:2 | ||||
| 10. Ronde | 06.09.2021 | River Plate | - | Independiente | 1:1 | ||||
| 11. Ronde | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 16. Ronde | 18.10.2021 | River Plate | - | San Lorenzo | 3:1 | ||||
| 25. Ronde | 11.12.2021 | Atlético Tucumán | - | River Plate | 1:1 |
Argentinië