| 1. Ronde | 08.01.2022 | Pumas UNAM [] | - | Cruz Azul [] | 2:1 |  |
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| 3. Ronde | 22.01.2022 | Pumas UNAM [] | - | FC Juárez [] | 2:1 | ||||
| 2. Ronde | 26.01.2022 | CF América [] | - | Pumas UNAM [] | 1:2 | |
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| 4. Ronde | 29.01.2022 | Deportivo Toluca [] | - | Pumas UNAM [] | 0:2 | |
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| 5. Ronde | 05.02.2022 | Pumas UNAM [] | - | CF Pachuca [] | 4:3 | |
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| 6. Ronde | 12.02.2022 | Gallos Blancos [] | - | Pumas UNAM [] | 1:3 | |
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| 7. Ronde | 19.02.2022 | Puebla FC [] | - | Pumas UNAM [] | 0:4 | ||||
| 9. Ronde | 05.03.2022 | Pumas UNAM [] | - | Club Necaxa [] | 1:1 | |
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| 10. Ronde | 16.03.2022 | FC Juárez [] | - | Pumas UNAM [] | 1:1 | |
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| 11. Ronde | 19.03.2022 | Pumas UNAM [] | - | CF América [] | 1:1 |
Mexico