| 1. Ronde | 16.08.2021 | Elche CF | - | Athletic Club | 0:0 | ||||
| 2. Ronde | 22.08.2021 | Atlético Madrid | - | Elche CF | 1:0 | ||||
| 4. Ronde | 13.09.2021 | Getafe CF | - | Elche CF | 0:1 | ||||
| 9. Ronde | 17.10.2021 | Rayo Vallecano | - | Elche CF | 2:1 | ||||
| 10. Ronde | 23.10.2021 | Elche CF | - | Espanyol | 2:2 |  |
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| 11. Ronde | 26.10.2021 | Deportivo Alavés | - | Elche CF | 1:0 | ||||
| 12. Ronde | 30.10.2021 | Elche CF | - | Real Madrid | 1:2 | ||||
| 13. Ronde | 07.11.2021 | RCD Mallorca | - | Elche CF | 2:2 | |
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| 14. Ronde | 21.11.2021 | Elche CF | - | Real Betis | 0:3 | ||||
| 19. Ronde | 02.01.2022 | Elche CF | - | Granada CF | 0:0 | ||||
| 23. Ronde | 05.02.2022 | Elche CF | - | Deportivo Alavés | 3:1 | ||||
| 25. Ronde | 18.02.2022 | Elche CF | - | Rayo Vallecano | 2:1 | ||||
| 26. Ronde | 25.02.2022 | Levante UD | - | Elche CF | 3:0 | ||||
| 30. Ronde | 03.04.2022 | Athletic Club | - | Elche CF | 2:1 | |
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| 32. Ronde | 16.04.2022 | Elche CF | - | RCD Mallorca | 3:0 |  |
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| 34. Ronde | 01.05.2022 | Elche CF | - | CA Osasuna | 1:1 | ||||
| 35. Ronde | 07.05.2022 | Cádiz CF | - | Elche CF | 3:0 | ||||
| 36. Ronde | 11.05.2022 | Elche CF | - | Atlético Madrid | 0:2 | |
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| 38. Ronde | 22.05.2022 | Elche CF | - | Getafe CF | 3:1 | |
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