| 12. Ronde | 24.10.2021 | SD Ponferradina | - | Real Oviedo | 1:2 | ||||
| 16. Ronde | 14.11.2021 | CD Leganés | - | Real Oviedo | 0:0 | ||||
| 17. Ronde | 20.11.2021 | Real Oviedo | - | SD Amorebieta | 2:0 | ||||
| 18. Ronde | 26.11.2021 | CD Mirandés | - | Real Oviedo | 1:1 |  |
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| 19. Ronde | 05.12.2021 | Real Oviedo | - | AD Alcorcón | 3:1 | ||||
| 20. Ronde | 12.12.2021 | Real Valladolid | - | Real Oviedo | 2:1 | ||||
| 21. Ronde | 19.12.2021 | CF Fuenlabrada | - | Real Oviedo | 0:0 | ||||
| 23. Ronde | 10.01.2022 | Real Oviedo | - | SD Eibar | 1:1 | ||||
| 24. Ronde | 21.01.2022 | CD Tenerife | - | Real Oviedo | 4:0 | |
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| 25. Ronde | 29.01.2022 | Real Oviedo | - | UD Almería | 2:0 | ||||
| 26. Ronde | 06.02.2022 | SD Amorebieta | - | Real Oviedo | 1:1 | ||||
| 27. Ronde | 13.02.2022 | Real Oviedo | - | SD Huesca | 3:3 |  |
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| 29. Ronde | 26.02.2022 | Real Oviedo | - | Real Sociedad B | 0:1 |  |
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| 31. Ronde | 13.03.2022 | Real Oviedo | - | Real Valladolid | 3:0 | ||||
| 37. Ronde | 24.04.2022 | AD Alcorcón | - | Real Oviedo | 1:2 | |
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| 38. Ronde | 30.04.2022 | Real Oviedo | - | CD Mirandés | 3:0 | ||||
| 39. Ronde | 07.05.2022 | Málaga CF | - | Real Oviedo | 0:0 | ||||
| 40. Ronde | 16.05.2022 | Real Oviedo | - | Real Zaragoza | 3:3 | ||||
| 41. Ronde | 21.05.2022 | UD Las Palmas | - | Real Oviedo | 2:1 | |
Spanje