| 3. Ronde | 22.01.2022 | Pumas UNAM [] | - | FC Juárez [] | 2:1 |  |
|||
| 2. Ronde | 26.01.2022 | CF América [] | - | Pumas UNAM [] | 1:2 | ||||
| 5. Ronde | 05.02.2022 | Pumas UNAM [] | - | CF Pachuca [] | 4:3 | ||||
| 7. Ronde | 19.02.2022 | Puebla FC [] | - | Pumas UNAM [] | 0:4 | ||||
| 10. Ronde | 16.03.2022 | FC Juárez [] | - | Pumas UNAM [] | 1:1 | ||||
| 11. Ronde | 19.03.2022 | Pumas UNAM [] | - | CF América [] | 1:1 | ||||
| 12. Ronde | 26.03.2022 | CF Pachuca [] | - | Pumas UNAM [] | 2:2 | ||||
| 16. Ronde | 23.04.2022 | Pumas UNAM [] | - | Deportivo Toluca [] | 3:1 | ||||
| 17. Ronde | 30.04.2022 | Club Necaxa [] | - | Pumas UNAM [] | 0:0 |
Mexico