| 1. Ronde | 14.08.2021 | İstanbulspor AŞ | - | Manisa FK | 3:4 |  |
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| 2. Ronde | 22.08.2021 | Manisa FK | - | Denizlispor | 1:0 | ||||
| 3. Ronde | 29.08.2021 | Gençlerbirliği | - | Manisa FK | 0:3 | ||||
| 4. Ronde | 11.09.2021 | Manisa FK | - | BB Erzurumspor | 0:1 | ||||
| 5. Ronde | 15.09.2021 | Menemen Belediyespor | - | Manisa FK | 2:0 | ||||
| 9. Ronde | 17.10.2021 | Manisa FK | - | Adanaspor | 0:3 |  |
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| 10. Ronde | 22.10.2021 | MKE Ankaragücü | - | Manisa FK | 2:1 | |
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| 11. Ronde | 30.10.2021 | Manisa FK | - | Boluspor | 2:2 | ||||
| 12. Ronde | 06.11.2021 | Samsunspor | - | Manisa FK | 1:0 |  |
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| 20. Ronde | 09.01.2022 | Manisa FK | - | İstanbulspor AŞ | 1:2 |
Jamaica