| 1. Ronde | 09.01.2022 | Santos Laguna [U16] | - | CF Monterrey [U16] | 0:0 | ||||
| 3. Ronde | 22.01.2022 | UANL Tigres [U16] | - | Santos Laguna [U16] | 0:2 | ||||
| 4. Ronde | 29.01.2022 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 0:1 |  |
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| 5. Ronde | 04.02.2022 | Atlético San Luis [U16] | - | Santos Laguna [U16] | 2:1 | ||||
| 6. Ronde | 12.02.2022 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 5:3 | ||||
| 7. Ronde | 18.02.2022 | Club León [U16] | - | Santos Laguna [U16] | 0:0 | ||||
| 8. Ronde | 26.02.2022 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 2:0 | ||||
| 9. Ronde | 05.03.2022 | Santos Laguna [U16] | - | Club Tijuana [U16] | 2:0 | ||||
| 12. Ronde | 26.03.2022 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 3:1 | ||||
| 13. Ronde | 02.04.2022 | CF Monterrey [U16] | - | Santos Laguna [U16] | 2:1 | |
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| 15. Ronde | 20.04.2022 | Club Tijuana [U16] | - | Santos Laguna [U16] | 0:1 |  |
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| 16. Ronde | 23.04.2022 | Santos Laguna [U16] | - | UANL Tigres [U16] | 5:0 | ||||
| 17. Ronde | 30.04.2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 3:0 | |
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| 18. Ronde | 07.05.2022 | Santos Laguna [U16] | - | Club León [U16] | 2:1 |
Mexico