| 1. Ronde | 14.08.2021 | SD Ponferradina | - | AD Alcorcón | 1:0 |  |
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| 2. Ronde | 22.08.2021 | SD Eibar | - | SD Ponferradina | 0:1 | ||||
| 3. Ronde | 28.08.2021 | SD Ponferradina | - | Girona FC | 2:1 | |
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| 4. Ronde | 04.09.2021 | CD Tenerife | - | SD Ponferradina | 2:0 | ||||
| 6. Ronde | 19.09.2021 | SD Ponferradina | - | Málaga CF | 4:0 | ||||
| 11. Ronde | 21.10.2021 | Real Zaragoza | - | SD Ponferradina | 1:1 | ||||
| 12. Ronde | 24.10.2021 | SD Ponferradina | - | Real Oviedo | 1:2 | ||||
| 13. Ronde | 30.10.2021 | FC Cartagena | - | SD Ponferradina | 0:1 | ||||
| 20. Ronde | 12.12.2021 | CD Leganés | - | SD Ponferradina | 1:1 | ||||
| 21. Ronde | 19.12.2021 | SD Ponferradina | - | SD Amorebieta | 1:1 | ||||
| 22. Ronde | 31.12.2021 | Real Oviedo | - | SD Ponferradina | 2:0 | ||||
| 26. Ronde | 05.02.2022 | Girona FC | - | SD Ponferradina | 3:0 | ||||
| 31. Ronde | 12.03.2022 | Málaga CF | - | SD Ponferradina | 0:0 | |
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| 34. Ronde | 03.04.2022 | SD Ponferradina | - | UD Las Palmas | 1:2 | ||||
| 36. Ronde | 17.04.2022 | SD Ponferradina | - | CD Lugo | 3:1 | ||||
| 37. Ronde | 23.04.2022 | CF Fuenlabrada | - | SD Ponferradina | 2:3 | ||||
| 42. Ronde | 28.05.2022 | SD Amorebieta | - | SD Ponferradina | 1:0 |
Spanje