| 1. Ronde | 08.01.2022 | Pumas UNAM [] | - | Cruz Azul [] | 2:1 | ||||
| 3. Ronde | 22.01.2022 | Pumas UNAM [] | - | FC Juárez [] | 2:1 | ||||
| 2. Ronde | 26.01.2022 | CF América [] | - | Pumas UNAM [] | 1:2 | ||||
| 4. Ronde | 29.01.2022 | Deportivo Toluca [] | - | Pumas UNAM [] | 0:2 | ||||
| 5. Ronde | 05.02.2022 | Pumas UNAM [] | - | CF Pachuca [] | 4:3 | ||||
| 6. Ronde | 12.02.2022 | Gallos Blancos [] | - | Pumas UNAM [] | 1:3 | ||||
| 7. Ronde | 19.02.2022 | Puebla FC [] | - | Pumas UNAM [] | 0:4 | ||||
| 9. Ronde | 05.03.2022 | Pumas UNAM [] | - | Club Necaxa [] | 1:1 | ||||
| 10. Ronde | 16.03.2022 | FC Juárez [] | - | Pumas UNAM [] | 1:1 | ||||
| 11. Ronde | 19.03.2022 | Pumas UNAM [] | - | CF América [] | 1:1 | ||||
| 15. Ronde | 23.03.2022 | Cruz Azul [] | - | Pumas UNAM [] | 1:4 | ||||
| 12. Ronde | 26.03.2022 | CF Pachuca [] | - | Pumas UNAM [] | 2:2 | ||||
| 14. Ronde | 30.03.2022 | Pumas UNAM [] | - | Gallos Blancos [] | 2:1 | ||||
| 17. Ronde | 30.04.2022 | Club Necaxa [] | - | Pumas UNAM [] | 0:0 | ||||
| 18. Ronde | 07.05.2022 | Pumas UNAM [] | - | Puebla FC [] | 2:1 |
Mexico