| 1. Ronde | 08.01.2022 | Pumas UNAM [U16] | - | Cruz Azul [U16] | 1:2 | ||||
| 2. Ronde | 15.01.2022 | CF América [U16] | - | Pumas UNAM [U16] | 1:0 | ||||
| 3. Ronde | 22.01.2022 | Pumas UNAM [U16] | - | FC Juárez [U16] | 3:0 |  |
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| 4. Ronde | 29.01.2022 | Deportivo Toluca [U16] | - | Pumas UNAM [U16] | 2:0 | ||||
| 5. Ronde | 05.02.2022 | Pumas UNAM [U16] | - | CF Pachuca [U16] | 4:0 | ||||
| 6. Ronde | 12.02.2022 | Gallos Blancos [U16] | - | Pumas UNAM [U16] | 0:1 |  |
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| 7. Ronde | 19.02.2022 | Puebla FC [U16] | - | Pumas UNAM [U16] | 0:1 | ||||
| 9. Ronde | 05.03.2022 | Pumas UNAM [U16] | - | Club Necaxa [U16] | 1:1 | ||||
| 10. Ronde | 12.03.2022 | FC Juárez [U16] | - | Pumas UNAM [U16] | 2:3 | ||||
| 11. Ronde | 19.03.2022 | Pumas UNAM [U16] | - | CF América [U16] | 1:0 | ||||
| 15. Ronde | 23.03.2022 | Cruz Azul [U16] | - | Pumas UNAM [U16] | 0:2 | ||||
| 12. Ronde | 26.03.2022 | CF Pachuca [U16] | - | Pumas UNAM [U16] | 0:0 | |
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| 14. Ronde | 30.03.2022 | Pumas UNAM [U16] | - | Gallos Blancos [U16] | 3:0 | ||||
| 16. Ronde | 23.04.2022 | Pumas UNAM [U16] | - | Deportivo Toluca [U16] | 3:4 | ||||
| 17. Ronde | 30.04.2022 | Club Necaxa [U16] | - | Pumas UNAM [U16] | 2:1 | ||||
| 18. Ronde | 07.05.2022 | Pumas UNAM [U16] | - | Puebla FC [U16] | 1:1 |
Mexico