| 1. Ronde | 14.08.2021 | Fatih Karagümrük | - | Gaziantep FK | 3:2 | ||||
| 2. Ronde | 21.08.2021 | Gaziantep FK | - | Beşiktaş | 0:0 | ||||
| 3. Ronde | 28.08.2021 | Yeni Malatyaspor | - | Gaziantep FK | 2:0 | ||||
| 5. Ronde | 18.09.2021 | Sivasspor | - | Gaziantep FK | 1:1 | ||||
| 6. Ronde | 22.09.2021 | Gaziantep FK | - | İstanbul Başakşehir | 1:0 | ||||
| 7. Ronde | 25.09.2021 | Adana Demirspor | - | Gaziantep FK | 4:0 | ||||
| 9. Ronde | 18.10.2021 | Hatayspor | - | Gaziantep FK | 2:1 |  |
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| 10. Ronde | 23.10.2021 | Gaziantep FK | - | Giresunspor | 1:1 | ||||
| 15. Ronde | 06.12.2021 | Göztepe | - | Gaziantep FK | 2:1 | |
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| 16. Ronde | 13.12.2021 | Gaziantep FK | - | Fenerbahçe | 3:2 | ||||
| 17. Ronde | 19.12.2021 | Kayserispor | - | Gaziantep FK | 0:0 |
Cyprus