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| 03.12.2021 | 18:00 | Kasımpaşa SK | - | Beşiktaş | 1:1 (0:1) | |
| 04.12.2021 | 11:30 | Alanyaspor | - | Sivasspor | 0:1 (0:0) | |
| 14:00 | Trabzonspor | - | Adana Demirspor | 2:0 (1:0) | ||
| 17:00 | Galatasaray | - | Altay Izmir | 2:2 (1:1) | ||
| 05.12.2021 | 11:30 | Kayserispor | - | Antalyaspor | 2:0 (2:0) | |
| 14:00 | Giresunspor | - | Fatih Karagümrük | 3:1 (0:1) | ||
| 14:00 | Hatayspor | - | İstanbul Başakşehir | 0:3 (0:3) | ||
| 17:00 | Fenerbahçe | - | Çaykur Rizespor | 4:0 (1:0) | ||
| 06.12.2021 | 18:00 | Göztepe | - | Gaziantep FK | 2:1 (2:0) | |
| 18:00 | Konyaspor | - | Yeni Malatyaspor | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 15 | 12 | 3 | 0 | 31:11 | 20 | 39 |
| 2 |
|
Konyaspor | 15 | 7 | 6 | 2 | 23:13 | 10 | 27 |
| 3 |
|
Fenerbahçe | 15 | 8 | 3 | 4 | 24:17 | 7 | 27 |
| 4 |
|
Hatayspor | 15 | 8 | 2 | 5 | 23:17 | 6 | 26 |
| 5 |
|
İstanbul Başakşehir | 15 | 8 | 1 | 6 | 23:16 | 7 | 25 |
| 6 |
|
Alanyaspor | 15 | 7 | 3 | 5 | 20:23 | -3 | 24 |
| 7 |
|
Galatasaray | 15 | 6 | 5 | 4 | 21:19 | 2 | 23 |
| 8 |
|
Fatih Karagümrük | 15 | 6 | 4 | 5 | 22:21 | 1 | 22 |
| 9 |
|
Beşiktaş | 15 | 6 | 3 | 6 | 22:22 | 0 | 21 |
| 10 |
|
Adana Demirspor | 15 | 5 | 5 | 5 | 20:20 | 0 | 20 |
| 11 |
|
Sivasspor | 15 | 4 | 7 | 4 | 21:15 | 6 | 19 |
| 12 |
|
Giresunspor | 15 | 5 | 4 | 6 | 15:13 | 2 | 19 |
| 13 |
|
Kayserispor | 15 | 5 | 4 | 6 | 20:22 | -2 | 19 |
| 14 |
|
Altay Izmir | 15 | 5 | 3 | 7 | 20:23 | -3 | 18 |
| 15 |
|
Antalyaspor | 15 | 5 | 3 | 7 | 18:22 | -4 | 18 |
| 16 |
|
Gaziantep FK | 15 | 5 | 3 | 7 | 18:23 | -5 | 18 |
| 17 |
|
Göztepe | 15 | 3 | 5 | 7 | 15:21 | -6 | 14 |
| 18 |
|
Yeni Malatyaspor | 15 | 4 | 2 | 9 | 12:23 | -11 | 14 |
| 19 |
|
Kasımpaşa SK | 15 | 2 | 5 | 8 | 14:22 | -8 | 11 |
| 20 |
|
Çaykur Rizespor | 15 | 3 | 1 | 11 | 12:31 | -19 | 10 |
| Champions League | |
| Champions League Kwali. | |
| Degradatie |
