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| 22.10.2021 | 19:00 | Yeni Malatyaspor | - | Altay Izmir | 2:1 (0:0) | |
| 23.10.2021 | 12:30 | Çaykur Rizespor | - | Kasımpaşa SK | 2:1 (1:0) | |
| 15:00 | Gaziantep FK | - | Giresunspor | 1:1 (0:0) | ||
| 15:00 | Konyaspor | - | Kayserispor | 2:0 (2:0) | ||
| 18:00 | Göztepe | - | Trabzonspor | 0:1 (0:0) | ||
| 24.10.2021 | 12:30 | Fatih Karagümrük SK | - | Hatayspor | 1:1 (1:1) | |
| 15:00 | Antalyaspor | - | İstanbul Başakşehir | 1:2 (0:1) | ||
| 15:00 | Sivasspor | - | Adana Demirspor | 1:1 (1:0) | ||
| 18:00 | Fenerbahçe | - | Alanyaspor | 1:2 (0:0) | ||
| 25.10.2021 | 19:00 | Beşiktaş | - | Galatasaray | 2:1 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 10 | 7 | 3 | 0 | 20:9 | 11 | 24 |
| 2 |
|
Hatayspor | 10 | 6 | 2 | 2 | 19:8 | 11 | 20 |
| 3 |
|
Beşiktaş | 10 | 6 | 2 | 2 | 20:12 | 8 | 20 |
| 4 |
|
Alanyaspor | 10 | 6 | 2 | 2 | 16:15 | 1 | 20 |
| 5 |
|
Fenerbahçe | 10 | 6 | 1 | 3 | 14:11 | 3 | 19 |
| 6 |
|
Fatih Karagümrük SK | 10 | 5 | 3 | 2 | 16:12 | 4 | 18 |
| 7 |
|
Konyaspor | 10 | 4 | 5 | 1 | 14:9 | 5 | 17 |
| 8 |
|
Galatasaray | 10 | 5 | 2 | 3 | 15:14 | 1 | 17 |
| 9 |
|
Altay Izmir | 10 | 5 | 0 | 5 | 16:16 | 0 | 15 |
| 10 |
|
Adana Demirspor | 10 | 3 | 4 | 3 | 15:15 | 0 | 13 |
| 11 |
|
İstanbul Başakşehir | 10 | 4 | 0 | 6 | 13:13 | 0 | 12 |
| 12 |
|
Gaziantep FK | 10 | 3 | 3 | 4 | 12:14 | -2 | 12 |
| 13 |
|
Yeni Malatyaspor | 10 | 4 | 0 | 6 | 11:17 | -6 | 12 |
| 14 |
|
Sivasspor | 10 | 2 | 5 | 3 | 14:12 | 2 | 11 |
| 15 |
|
Kayserispor | 10 | 3 | 2 | 5 | 13:17 | -4 | 11 |
| 16 |
|
Giresunspor | 10 | 2 | 3 | 5 | 6:10 | -4 | 9 |
| 17 |
|
Antalyaspor | 10 | 2 | 3 | 5 | 11:16 | -5 | 9 |
| 18 |
|
Göztepe | 10 | 2 | 2 | 6 | 9:14 | -5 | 8 |
| 19 |
|
Kasımpaşa SK | 10 | 1 | 3 | 6 | 10:16 | -6 | 6 |
| 20 |
|
Çaykur Rizespor | 10 | 1 | 1 | 8 | 8:22 | -14 | 4 |
| Champions League | |
| Champions League Kwali. | |
| Degradatie |
