| 1. Ronde | 08.01.2022 | CF Pachuca [] | - | Puebla FC [] | 2:0 | ||||
| 7. Ronde | 19.02.2022 | CF Pachuca [] | - | Gallos Blancos [] | 3:0 | ||||
| 8. Ronde | 26.02.2022 | CF Pachuca [] | - | FC Juárez [] | 4:0 | ||||
| 10. Ronde | 12.03.2022 | CF Pachuca [] | - | Cruz Azul [] | 4:2 | ||||
| 16. Ronde | 24.04.2022 | CF América [] | - | CF Pachuca [] | 4:3 | ||||
| 17. Ronde | 30.04.2022 | CF Pachuca [] | - | Deportivo Toluca [] | 0:2 |
Mexico