| 2. Ronde | 15.01.2022 | Cruz Azul [] | - | CF Pachuca [] | 1:4 | ||||
| 5. Ronde | 05.02.2022 | Pumas UNAM [] | - | CF Pachuca [] | 4:3 | ||||
| 6. Ronde | 12.02.2022 | Club Necaxa [] | - | CF Pachuca [] | 2:1 | ||||
| 7. Ronde | 19.02.2022 | CF Pachuca [] | - | Gallos Blancos [] | 3:0 | ||||
| 11. Ronde | 19.03.2022 | Puebla FC [] | - | CF Pachuca [] | 0:3 | ||||
| 13. Ronde | 03.04.2022 | FC Juárez [] | - | CF Pachuca [] | 1:4 | ||||
| 14. Ronde | 09.04.2022 | CF Pachuca [] | - | Club Necaxa [] | 0:1 | ||||
| 16. Ronde | 24.04.2022 | CF América [] | - | CF Pachuca [] | 4:3 | ||||
| 17. Ronde | 30.04.2022 | CF Pachuca [] | - | Deportivo Toluca [] | 0:2 | ||||
| 18. Ronde | 07.05.2022 | Gallos Blancos [] | - | CF Pachuca [] | 0:0 |
Mexico