| 1. Ronde | 15.08.2021 | Sporting Gijón | - | Burgos CF | 1:0 | ||||
| 2. Ronde | 21.08.2021 | CD Tenerife | - | Sporting Gijón | 0:0 | ||||
| 3. Ronde | 28.08.2021 | Sporting Gijón | - | CD Mirandés | 2:1 |  |
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| 4. Ronde | 03.09.2021 | Girona FC | - | Sporting Gijón | 1:2 |  |
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| 5. Ronde | 10.09.2021 | Sporting Gijón | - | CD Leganés | 2:1 | ||||
| 6. Ronde | 19.09.2021 | SD Eibar | - | Sporting Gijón | 3:2 | ||||
| 7. Ronde | 26.09.2021 | Sporting Gijón | - | Málaga CF | 2:1 | ||||
| 9. Ronde | 09.10.2021 | Real Oviedo | - | Sporting Gijón | 1:1 | ||||
| 11. Ronde | 19.10.2021 | FC Cartagena | - | Sporting Gijón | 1:0 | ||||
| 12. Ronde | 23.10.2021 | Sporting Gijón | - | Real Valladolid | 1:2 | |
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| 13. Ronde | 30.10.2021 | CD Lugo | - | Sporting Gijón | 1:1 | ||||
| 16. Ronde | 12.11.2021 | Sporting Gijón | - | Real Sociedad B | 0:1 | ||||
| 21. Ronde | 18.12.2021 | UD Ibiza | - | Sporting Gijón | 0:2 | ||||
| 26. Ronde | 05.02.2022 | Sporting Gijón | - | SD Eibar | 0:1 | ||||
| 27. Ronde | 12.02.2022 | CD Mirandés | - | Sporting Gijón | 0:3 | ||||
| 28. Ronde | 20.02.2022 | Sporting Gijón | - | SD Ponferradina | 2:3 |
Spanje