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| 10.09.2021 | 21:00 | Sporting Gijón | - | CD Leganés | 2:1 (1:0) | |
| 11.09.2021 | 16:00 | SD Amorebieta | - | Burgos CF | 2:2 (1:1) | |
| 16:00 | Real Sociedad B | - | SD Eibar | 2:3 (0:1) | ||
| 18:15 | UD Las Palmas | - | UD Ibiza | 1:1 (0:1) | ||
| 21:00 | CD Mirandés | - | AD Alcorcón | 1:3 (1:1) | ||
| 12.09.2021 | 14:00 | Real Oviedo | - | FC Cartagena | 2:0 (1:0) | |
| 16:00 | Real Valladolid | - | CD Tenerife | 0:2 (0:2) | ||
| 18:15 | SD Ponferradina | - | UD Almería | 1:0 (0:0) | ||
| 20:30 | CF Fuenlabrada | - | Real Zaragoza | 1:1 (1:0) | ||
| 21:30 | Málaga CF | - | Girona FC | 2:0 (1:0) | ||
| 13.09.2021 | 21:00 | CD Lugo | - | SD Huesca | 3:2 (1:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sporting Gijón | 5 | 4 | 1 | 0 | 7:3 | 4 | 13 |
| 2 |
|
SD Ponferradina | 5 | 4 | 0 | 1 | 5:3 | 2 | 12 |
| 3 |
|
CD Tenerife | 5 | 3 | 2 | 0 | 6:1 | 5 | 11 |
| 4 |
|
UD Almería | 5 | 3 | 0 | 2 | 8:5 | 3 | 9 |
| 5 |
|
Málaga CF | 5 | 2 | 2 | 1 | 5:4 | 1 | 8 |
| 6 |
|
Real Oviedo | 5 | 2 | 2 | 1 | 7:5 | 2 | 8 |
| 7 |
|
CD Mirandés | 5 | 2 | 1 | 2 | 8:7 | 1 | 7 |
| 8 |
|
UD Ibiza | 5 | 1 | 4 | 0 | 6:5 | 1 | 7 |
| 9 |
|
SD Eibar | 5 | 2 | 1 | 2 | 5:6 | -1 | 7 |
| 10 |
|
Real Valladolid | 5 | 2 | 1 | 2 | 5:6 | -1 | 7 |
| 11 |
|
CF Fuenlabrada | 5 | 1 | 3 | 1 | 5:4 | 1 | 6 |
| 12 |
|
CD Lugo | 5 | 1 | 3 | 1 | 6:7 | -1 | 6 |
|
UD Las Palmas | 5 | 1 | 3 | 1 | 6:7 | -1 | 6 | |
| 14 |
|
FC Cartagena | 5 | 2 | 0 | 3 | 3:7 | -4 | 6 |
| 15 |
|
SD Huesca | 5 | 2 | 0 | 3 | 8:7 | 1 | 6 |
| 16 |
|
Real Sociedad B | 5 | 1 | 2 | 2 | 3:4 | -1 | 5 |
| 17 |
|
Real Zaragoza | 5 | 1 | 2 | 2 | 3:5 | -2 | 5 |
| 18 |
|
SD Amorebieta | 5 | 1 | 2 | 2 | 5:8 | -3 | 5 |
| 19 |
|
Burgos CF | 5 | 1 | 2 | 2 | 5:4 | 1 | 5 |
| 20 |
|
Girona FC | 5 | 1 | 1 | 3 | 4:6 | -2 | 4 |
| 21 |
|
AD Alcorcón | 5 | 1 | 0 | 4 | 4:7 | -3 | 3 |
| 22 |
|
CD Leganés | 5 | 0 | 2 | 3 | 3:6 | -3 | 2 |
| Promotie | |
| Play-offs | |
| Degradatie |
