| 1. Ronde | 08.01.2022 | CF Pachuca [] | - | Puebla FC [] | 2:0 | ||||
| 2. Ronde | 15.01.2022 | Puebla FC [] | - | Gallos Blancos [] | 0:0 | ||||
| 5. Ronde | 05.02.2022 | Club Necaxa [] | - | Puebla FC [] | 4:0 | ||||
| 3. Ronde | 09.02.2022 | CF América [] | - | Puebla FC [] | 1:0 | ||||
| 6. Ronde | 12.02.2022 | Puebla FC [] | - | Deportivo Toluca [] | 0:4 | ||||
| 7. Ronde | 19.02.2022 | Puebla FC [] | - | Pumas UNAM [] | 0:4 | ||||
| 8. Ronde | 26.02.2022 | Cruz Azul [] | - | Puebla FC [] | 4:1 |  |
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| 9. Ronde | 05.03.2022 | Puebla FC [] | - | FC Juárez [] | 3:2 | |
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| 11. Ronde | 19.03.2022 | Puebla FC [] | - | CF Pachuca [] | 0:3 | ||||
| 12. Ronde | 26.03.2022 | Puebla FC [] | - | Club Necaxa [] | 0:3 | ||||
| 13. Ronde | 02.04.2022 | Gallos Blancos [] | - | Puebla FC [] | 0:3 | ||||
| 15. Ronde | 16.04.2022 | FC Juárez [] | - | Puebla FC [] | 4:0 | ||||
| 16. Ronde | 23.04.2022 | Puebla FC [] | - | Cruz Azul [] | 0:2 | ||||
| 17. Ronde | 30.04.2022 | Puebla FC [] | - | CF América [] | 2:3 | |
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| 18. Ronde | 07.05.2022 | Pumas UNAM [] | - | Puebla FC [] | 2:1 | |
Mexico