| 22. Ronde | 05.02.2022 | UCAM Murcia CF | - | CD Alcoyano | 1:2 |  |
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| 24. Ronde | 20.02.2022 | UCAM Murcia CF | - | CE Sabadell | 1:1 | ||||
| 25. Ronde | 27.02.2022 | UCAM Murcia CF | - | San Fernando CD | 2:3 | ||||
| 26. Ronde | 06.03.2022 | Sevilla Atlético | - | UCAM Murcia CF | 0:2 | ||||
| 27. Ronde | 13.03.2022 | UCAM Murcia CF | - | Villarreal CF B | 2:3 | |
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| 28. Ronde | 19.03.2022 | Atlético Sanluqueño CF | - | UCAM Murcia CF | 1:1 |  |
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| 29. Ronde | 25.03.2022 | Albacete | - | UCAM Murcia CF | 3:1 | ||||
| 23. Ronde | 30.03.2022 | Real Madrid Castilla | - | UCAM Murcia CF | 3:0 | ||||
| 33. Ronde | 24.04.2022 | Algeciras CF | - | UCAM Murcia CF | 1:1 | |
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| 35. Ronde | 07.05.2022 | UE Costa Brava | - | UCAM Murcia CF | 3:0 | ||||
| 36. Ronde | 15.05.2022 | UCAM Murcia CF | - | Atlético Baleares | 1:1 | ||||
| 37. Ronde | 21.05.2022 | FC Andorra | - | UCAM Murcia CF | 1:0 | ||||
| 38. Ronde | 28.05.2022 | UCAM Murcia CF | - | FC Barcelona B | 1:2 |
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