| 1. Ronde | 18.07.2021 | Arsenal de Sarandí | - | San Lorenzo | 1:1 | ||||
| 7. Ronde | 22.08.2021 | San Lorenzo | - | Argentinos Juniors | 0:1 | ||||
| 8. Ronde | 26.08.2021 | Estudiantes | - | San Lorenzo | 2:0 |  |
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| 9. Ronde | 30.08.2021 | San Lorenzo | - | Patronato de Paraná | 3:0 | ||||
| 10. Ronde | 04.09.2021 | Platense | - | San Lorenzo | 1:1 | |
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| 11. Ronde | 13.09.2021 | San Lorenzo | - | Racing Club | 1:1 | ||||
| 12. Ronde | 20.09.2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 13. Ronde | 26.09.2021 | San Lorenzo | - | Defensa y Justicia | 2:1 |  |
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| 14. Ronde | 02.10.2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | |
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| 15. Ronde | 11.10.2021 | San Lorenzo | - | Colón de Santa Fe | 1:2 | ||||
| 16. Ronde | 18.10.2021 | River Plate | - | San Lorenzo | 3:1 | |
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| 17. Ronde | 20.10.2021 | San Lorenzo | - | Lanús | 1:3 | |
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| 19. Ronde | 31.10.2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
| 20. Ronde | 07.11.2021 | Vélez Sarsfield | - | San Lorenzo | 2:1 | ||||
| 21. Ronde | 19.11.2021 | San Lorenzo | - | Gimnasia de La Plata | 0:1 | ||||
| 22. Ronde | 23.11.2021 | Aldosivi | - | San Lorenzo | 2:0 |  |
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| 24. Ronde | 05.12.2021 | Independiente | - | San Lorenzo | 1:1 | ||||
| 25. Ronde | 12.12.2021 | San Lorenzo | - | Newell's Old Boys | 3:2 |
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