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| 24.04.2021 | 02:15 | Godoy Cruz | - | Central Córdoba SdE | 1:0 (1:0) | |
| 18:30 | Patronato de Paraná | - | Sarmiento de Junín | 1:0 (0:0) | ||
| 20:45 | Argentinos Juniors | - | Banfield | 1:1 (0:0) | ||
| 23:00 | Huracán | - | Boca Juniors | 0:2 (0:0) | ||
| 25.04.2021 | 02:00 | Unión de Santa Fe | - | Independiente | 0:0 (0:0) | |
| 16:00 | Lanús | - | Vélez Sarsfield | 1:2 (0:0) | ||
| 18:30 | Defensa y Justicia | - | Arsenal de Sarandí | 0:1 (0:1) | ||
| 20:45 | Racing Club | - | Colón de Santa Fe | 2:1 (1:1) | ||
| 23:00 | River Plate | - | San Lorenzo | 1:2 (0:1) | ||
| 26.04.2021 | 02:00 | Rosario Central | - | Estudiantes | 0:1 (0:0) | |
| 02:00 | Atlético Tucumán | - | Talleres de Córdoba | 2:3 (1:1) | ||
| 20:45 | Platense | - | Aldosivi | 0:2 (0:0) | ||
| 23:00 | Gimnasia de La Plata | - | Newell's Old Boys | 2:1 (0:0) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Colón de Santa Fe | 11 | 6 | 3 | 2 | 20:9 | 11 | 21 |
| 2 |
|
Estudiantes | 11 | 5 | 4 | 2 | 14:8 | 6 | 19 |
| 3 |
|
River Plate | 11 | 5 | 3 | 3 | 21:9 | 12 | 18 |
| 4 |
|
San Lorenzo | 11 | 5 | 3 | 3 | 15:14 | 1 | 18 |
| 5 |
|
Racing Club | 11 | 5 | 3 | 3 | 12:11 | 1 | 18 |
| 6 |
|
Rosario Central | 11 | 4 | 3 | 4 | 12:14 | -2 | 15 |
| 7 |
|
Godoy Cruz | 11 | 4 | 3 | 4 | 18:22 | -4 | 15 |
| 8 |
|
Banfield | 11 | 3 | 5 | 3 | 12:12 | 0 | 14 |
| 9 |
|
Argentinos Juniors | 11 | 3 | 4 | 4 | 9:10 | -1 | 13 |
| 10 |
|
Central Córdoba SdE | 11 | 3 | 4 | 4 | 12:16 | -4 | 13 |
| 11 |
|
Aldosivi | 11 | 3 | 2 | 6 | 13:14 | -1 | 11 |
| 12 |
|
Platense | 11 | 3 | 2 | 6 | 8:16 | -8 | 11 |
| 13 |
|
Arsenal de Sarandí | 11 | 3 | 2 | 6 | 10:20 | -10 | 11 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Vélez Sarsfield | 11 | 8 | 1 | 2 | 17:13 | 4 | 25 |
| 2 |
|
Boca Juniors | 11 | 5 | 4 | 2 | 21:11 | 10 | 19 |
| 3 |
|
Talleres de Córdoba | 11 | 5 | 4 | 2 | 18:14 | 4 | 19 |
| 4 |
|
Independiente | 11 | 5 | 2 | 4 | 13:8 | 5 | 17 |
| 5 |
|
Lanús | 11 | 5 | 1 | 5 | 17:17 | 0 | 16 |
| 6 |
|
Unión de Santa Fe | 11 | 3 | 6 | 2 | 10:13 | -3 | 15 |
| 7 |
|
Gimnasia de La Plata | 11 | 3 | 5 | 3 | 15:15 | 0 | 14 |
| 8 |
|
Defensa y Justicia | 11 | 3 | 3 | 5 | 15:15 | 0 | 12 |
| 9 |
|
Huracán | 11 | 2 | 6 | 3 | 12:13 | -1 | 12 |
| 10 |
|
Atlético Tucumán | 11 | 3 | 3 | 5 | 18:20 | -2 | 12 |
| 11 |
|
Newell's Old Boys | 11 | 2 | 4 | 5 | 13:17 | -4 | 10 |
| 12 |
|
Sarmiento de Junín | 11 | 2 | 4 | 5 | 9:18 | -9 | 10 |
| 13 |
|
Patronato de Paraná | 11 | 3 | 0 | 8 | 11:16 | -5 | 9 |
| Play-offs | |
| Play-offs |
