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| 08.05.2021 | 18:00 | Godoy Cruz | - | Banfield | 0:1 (0:0) | |
| 20:30 | Atlético Tucumán | - | Defensa y Justicia | 5:0 (2:0) | ||
| 20:30 | Gimnasia de La Plata | - | Vélez Sarsfield | 0:5 (0:3) | ||
| 23:00 | Patronato de Paraná | - | Boca Juniors | 1:0 (0:0) | ||
| 09.05.2021 | 15:00 | Arsenal de Sarandí | - | Central Córdoba SdE | 1:1 (1:1) | |
| 17:10 | Argentinos Juniors | - | Estudiantes | 2:0 (2:0) | ||
| 19:30 | Racing Club | - | San Lorenzo | 2:0 (1:0) | ||
| 19:30 | River Plate | - | Aldosivi | 4:1 (2:1) | ||
| 19:30 | Platense | - | Rosario Central | 4:1 (1:1) | ||
| 23:00 | Huracán | - | Independiente | 1:3 (1:1) | ||
| 23:00 | Lanús | - | Talleres de Córdoba | 1:0 (1:0) | ||
| 23:00 | Colón de Santa Fe | - | Unión de Santa Fe | 1:1 (1:0) | ||
| 10.05.2021 | 02:00 | Newell's Old Boys | - | Sarmiento de Junín | 1:1 (1:0) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Colón de Santa Fe | 13 | 7 | 4 | 2 | 23:10 | 13 | 25 |
| 2 |
|
Estudiantes | 13 | 6 | 4 | 3 | 16:10 | 6 | 22 |
| 3 |
|
River Plate | 13 | 6 | 3 | 4 | 25:11 | 14 | 21 |
| 4 |
|
Racing Club | 13 | 6 | 3 | 4 | 14:12 | 2 | 21 |
| 5 |
|
San Lorenzo | 13 | 6 | 3 | 4 | 16:16 | 0 | 21 |
| 6 |
|
Banfield | 13 | 5 | 5 | 3 | 14:12 | 2 | 20 |
| 7 |
|
Argentinos Juniors | 13 | 5 | 4 | 4 | 14:11 | 3 | 19 |
| 8 |
|
Rosario Central | 13 | 5 | 3 | 5 | 16:18 | -2 | 18 |
| 9 |
|
Central Córdoba SdE | 13 | 4 | 5 | 4 | 14:17 | -3 | 17 |
| 10 |
|
Godoy Cruz | 13 | 4 | 3 | 6 | 18:24 | -6 | 15 |
| 11 |
|
Platense | 13 | 4 | 2 | 7 | 12:19 | -7 | 14 |
| 12 |
|
Arsenal de Sarandí | 13 | 3 | 3 | 7 | 11:23 | -12 | 12 |
| 13 |
|
Aldosivi | 13 | 3 | 2 | 8 | 15:21 | -6 | 11 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Vélez Sarsfield | 13 | 10 | 1 | 2 | 23:13 | 10 | 31 |
| 2 |
|
Boca Juniors | 13 | 6 | 4 | 3 | 22:12 | 10 | 22 |
| 3 |
|
Independiente | 13 | 6 | 2 | 5 | 16:10 | 6 | 20 |
| 4 |
|
Talleres de Córdoba | 13 | 5 | 5 | 3 | 19:16 | 3 | 20 |
| 5 |
|
Lanús | 13 | 6 | 1 | 6 | 18:18 | 0 | 19 |
| 6 |
|
Unión de Santa Fe | 13 | 4 | 7 | 2 | 12:14 | -2 | 19 |
| 7 |
|
Atlético Tucumán | 13 | 5 | 3 | 5 | 24:20 | 4 | 18 |
| 8 |
|
Gimnasia de La Plata | 13 | 3 | 6 | 4 | 15:20 | -5 | 15 |
| 9 |
|
Huracán | 13 | 2 | 7 | 4 | 14:17 | -3 | 13 |
| 10 |
|
Patronato de Paraná | 13 | 4 | 0 | 9 | 12:17 | -5 | 12 |
| 11 |
|
Defensa y Justicia | 13 | 3 | 3 | 7 | 15:21 | -6 | 12 |
| 12 |
|
Sarmiento de Junín | 13 | 2 | 6 | 5 | 10:19 | -9 | 12 |
| 13 |
|
Newell's Old Boys | 13 | 2 | 5 | 6 | 14:21 | -7 | 11 |
| Play-offs | |
| Play-offs |
