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| 03.09.2021 | 14:00 | Estudiantes II | - | Argentinos Juniors II | 2:0 (1:0) | |
| 15:00 | Huracán II | - | Aldosivi II | 2:1 (0:1) | ||
| 15:00 | Patronato de Paraná II | - | Talleres de Córdoba II | 0:2 (0:1) | ||
| 15:00 | Defensa y Justicia II | - | Central Córdoba SdE II | 0:1 (0:0) | ||
| 15:00 | Rosario Central II | - | Boca Juniors II | 1:3 (1:2) | ||
| 15:00 | Vélez Sarsfield II | - | Unión de Santa Fe II | 2:2 (1:2) | ||
| 16:00 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 (1:0) | ||
| 19:00 | Lanús II | - | Sarmiento de Junín II | 2:0 (0:0) | ||
| 04.09.2021 | 13:00 | Atlético Tucumán II | - | Arsenal de Sarandí II | 0:1 (0:0) | |
| 05.09.2021 | 15:00 | Godoy Cruz II | - | Gimnasia de La Plata II | 3:0 (0:0) | |
| 16:00 | Platense II | - | San Lorenzo II | 1:1 (0:0) | ||
| 06.09.2021 | 15:00 | River Plate II | - | Independiente II | 4:0 (2:0) | |
| 20:00 | Racing Club II | - | Banfield II | 1:2 (0:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lanús II | 10 | 7 | 1 | 2 | 18:5 | 13 | 22 |
| 2 |
|
Estudiantes II | 10 | 6 | 4 | 0 | 20:12 | 8 | 22 |
| 3 |
|
Colón de Santa Fe II | 10 | 6 | 3 | 1 | 11:5 | 6 | 21 |
| 4 |
|
Gimnasia de La Plata II | 10 | 6 | 1 | 3 | 18:13 | 5 | 19 |
| 5 |
|
Rosario Central II | 10 | 5 | 3 | 2 | 23:13 | 10 | 18 |
| 6 |
|
River Plate II | 10 | 6 | 0 | 4 | 17:10 | 7 | 18 |
| 7 |
|
Banfield II | 10 | 5 | 3 | 2 | 16:13 | 3 | 18 |
| 8 |
|
Boca Juniors II | 10 | 5 | 2 | 3 | 22:10 | 12 | 17 |
| 9 |
|
Platense II | 10 | 5 | 2 | 3 | 12:11 | 1 | 17 |
| 10 |
|
Argentinos Juniors II | 10 | 5 | 1 | 4 | 11:12 | -1 | 16 |
| 11 |
|
Talleres de Córdoba II | 10 | 4 | 3 | 3 | 12:12 | 0 | 15 |
| 12 |
|
Defensa y Justicia II | 10 | 4 | 3 | 3 | 10:13 | -3 | 15 |
| 13 |
|
Sarmiento de Junín II | 10 | 4 | 2 | 4 | 14:14 | 0 | 14 |
| 14 |
|
Atlético Tucumán II | 10 | 3 | 4 | 3 | 12:11 | 1 | 13 |
| 15 |
|
Vélez Sarsfield II | 10 | 3 | 4 | 3 | 11:14 | -3 | 13 |
| 16 |
|
Godoy Cruz II | 10 | 3 | 3 | 4 | 13:15 | -2 | 12 |
| 17 |
|
Patronato de Paraná II | 10 | 3 | 3 | 4 | 13:16 | -3 | 12 |
| 18 |
|
Arsenal de Sarandí II | 10 | 3 | 2 | 5 | 10:14 | -4 | 11 |
| 19 |
|
Newell's Old Boys II | 10 | 2 | 4 | 4 | 13:17 | -4 | 10 |
| 20 |
|
San Lorenzo II | 10 | 2 | 4 | 4 | 12:17 | -5 | 10 |
| 21 |
|
Unión de Santa Fe II | 10 | 2 | 3 | 5 | 9:15 | -6 | 9 |
| 22 |
|
Huracán II | 10 | 2 | 2 | 6 | 8:13 | -5 | 8 |
|
Independiente II | 10 | 1 | 5 | 4 | 8:13 | -5 | 8 | |
| 24 |
|
Racing Club II | 10 | 1 | 4 | 5 | 9:16 | -7 | 7 |
| 25 |
|
Central Córdoba SdE II | 10 | 2 | 0 | 8 | 8:15 | -7 | 6 |
| 26 |
|
Aldosivi II | 10 | 2 | 0 | 8 | 10:21 | -11 | 6 |
