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| 20.08.2022 | 15:00 | Independiente II | - | Godoy Cruz II | 0:2 (0:1) | |
| 16:00 | Sarmiento de Junín II | - | Vélez Sarsfield II | 0:2 (0:1) | ||
| 21.08.2022 | 15:00 | Newell's Old Boys II | - | Huracán II | 2:1 (1:0) | |
| 15:00 | Arsenal de Sarandí II | - | Lanús II | 2:3 (1:3) | ||
| 15:00 | Tigre II | - | Colón de Santa Fe II | 1:1 (0:1) | ||
| 15:00 | Barracas Central II | - | Atlético Tucumán II | 2:0 (0:0) | ||
| 22.08.2022 | 15:00 | Boca Juniors II | - | Defensa y Justicia II | 3:0 (0:0) | |
| 16:00 | Aldosivi II | - | Gimnasia de La Plata II | 1:2 (1:0) | ||
| 16:00 | Talleres de Córdoba II | - | Platense II | 0:0 (0:0) | ||
| 16:00 | Argentinos Juniors II | - | Patronato de Paraná II | 2:0 (1:0) | ||
| 23.08.2022 | 15:00 | San Lorenzo II | - | Racing Club II | 2:0 (1:0) | |
| 16:00 | Banfield II | - | Rosario Central II | 2:2 (1:1) | ||
| 16:00 | Unión de Santa Fe II | - | Estudiantes II | 0:0 (0:0) | ||
| 16:00 | Central Córdoba SdE II | - | River Plate II | 1:0 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 15 | 10 | 1 | 4 | 29:10 | 19 | 31 |
| 2 |
|
Vélez Sarsfield II | 15 | 9 | 2 | 4 | 29:10 | 19 | 29 |
| 3 |
|
Newell's Old Boys II | 15 | 8 | 5 | 2 | 21:12 | 9 | 29 |
| 4 |
|
River Plate II | 15 | 9 | 1 | 5 | 19:11 | 8 | 28 |
| 5 |
|
Argentinos Juniors II | 15 | 7 | 5 | 3 | 24:15 | 9 | 26 |
| 6 |
|
Defensa y Justicia II | 15 | 8 | 2 | 5 | 18:18 | 0 | 26 |
| 7 |
|
Rosario Central II | 15 | 7 | 4 | 4 | 29:23 | 6 | 25 |
| 8 |
|
Gimnasia de La Plata II | 15 | 7 | 4 | 4 | 23:17 | 6 | 25 |
| 9 |
|
Huracán II | 15 | 7 | 3 | 5 | 27:25 | 2 | 24 |
| 10 |
|
Lanús II | 15 | 7 | 1 | 7 | 27:29 | -2 | 22 |
| 11 |
|
Tigre II | 15 | 6 | 4 | 5 | 16:18 | -2 | 22 |
| 12 |
|
Atlético Tucumán II | 15 | 6 | 3 | 6 | 22:21 | 1 | 21 |
| 13 |
|
Central Córdoba SdE II | 15 | 6 | 3 | 6 | 16:20 | -4 | 21 |
| 14 |
|
Colón de Santa Fe II | 15 | 5 | 6 | 4 | 17:22 | -5 | 21 |
| 15 |
|
Independiente II | 15 | 5 | 4 | 6 | 22:21 | 1 | 19 |
| 16 |
|
Unión de Santa Fe II | 15 | 4 | 7 | 4 | 13:13 | 0 | 19 |
| 17 |
|
Racing Club II | 15 | 4 | 6 | 5 | 22:17 | 5 | 18 |
| 18 |
|
Arsenal de Sarandí II | 15 | 4 | 6 | 5 | 15:13 | 2 | 18 |
| 19 |
|
San Lorenzo II | 15 | 5 | 3 | 7 | 19:20 | -1 | 18 |
| 20 |
|
Banfield II | 15 | 4 | 5 | 6 | 12:15 | -3 | 17 |
| 21 |
|
Talleres de Córdoba II | 15 | 4 | 4 | 7 | 15:20 | -5 | 16 |
| 22 |
|
Estudiantes II | 15 | 3 | 7 | 5 | 11:16 | -5 | 16 |
| 23 |
|
Godoy Cruz II | 15 | 4 | 4 | 7 | 16:22 | -6 | 16 |
| 24 |
|
Aldosivi II | 15 | 5 | 1 | 9 | 25:35 | -10 | 16 |
| 25 |
|
Platense II | 15 | 2 | 8 | 5 | 10:14 | -4 | 14 |
| 26 |
|
Sarmiento de Junín II | 15 | 4 | 2 | 9 | 13:25 | -12 | 14 |
| 27 |
|
Patronato de Paraná II | 15 | 4 | 2 | 9 | 12:25 | -13 | 14 |
| 28 |
|
Barracas Central II | 15 | 4 | 1 | 10 | 9:24 | -15 | 13 |
