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| 22.09.2022 | 15:00 | Platense II | - | Rosario Central II | 2:2 (0:2) | |
| 15:00 | Patronato de Paraná II | - | Defensa y Justicia II | 0:4 (0:3) | ||
| 16:00 | Newell's Old Boys II | - | Independiente II | 2:1 (1:1) | ||
| 23.09.2022 | 15:00 | Tigre II | - | Gimnasia de La Plata II | 2:2 (0:1) | |
| 16:00 | Unión de Santa Fe II | - | Racing Club II | 0:2 (0:0) | ||
| 16:00 | Estudiantes II | - | Atlético Tucumán II | 5:2 (3:2) | ||
| 16:00 | Arsenal de Sarandí II | - | Sarmiento de Junín II | 2:0 (2:0) | ||
| 24.09.2022 | 15:00 | Talleres de Córdoba II | - | River Plate II | 5:0 (3:0) | |
| 15:00 | Barracas Central II | - | Vélez Sarsfield II | 3:2 (2:2) | ||
| 15:00 | Central Córdoba SdE II | - | Aldosivi II | 3:0 (1:0) | ||
| 25.09.2022 | 16:00 | Argentinos Juniors II | - | Colón de Santa Fe II | 2:2 (0:2) | |
| 16:00 | San Lorenzo II | - | Lanús II | 1:2 (0:2) | ||
| 16:00 | Banfield II | - | Huracán II | 4:2 (2:0) | ||
| 16:00 | Boca Juniors II | - | Godoy Cruz II | 0:0 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 21 | 13 | 3 | 5 | 36:16 | 20 | 42 |
| 2 |
|
Vélez Sarsfield II | 21 | 12 | 2 | 7 | 35:15 | 20 | 38 |
| 3 |
|
Newell's Old Boys II | 21 | 10 | 7 | 4 | 30:21 | 9 | 37 |
| 4 |
|
Argentinos Juniors II | 21 | 9 | 9 | 3 | 30:18 | 12 | 36 |
| 5 |
|
Huracán II | 21 | 11 | 3 | 7 | 43:33 | 10 | 36 |
| 6 |
|
Tigre II | 21 | 10 | 6 | 5 | 26:22 | 4 | 36 |
| 7 |
|
Independiente II | 21 | 10 | 4 | 7 | 35:26 | 9 | 34 |
| 8 |
|
Defensa y Justicia II | 21 | 10 | 4 | 7 | 25:22 | 3 | 34 |
| 9 |
|
River Plate II | 21 | 11 | 1 | 9 | 23:22 | 1 | 34 |
| 10 |
|
Gimnasia de La Plata II | 21 | 9 | 6 | 6 | 36:27 | 9 | 33 |
| 11 |
|
Talleres de Córdoba II | 21 | 9 | 4 | 8 | 32:27 | 5 | 31 |
| 12 |
|
Lanús II | 21 | 9 | 4 | 8 | 32:34 | -2 | 31 |
| 13 |
|
Rosario Central II | 21 | 8 | 6 | 7 | 34:30 | 4 | 30 |
| 14 |
|
Banfield II | 21 | 8 | 6 | 7 | 22:20 | 2 | 30 |
| 15 |
|
San Lorenzo II | 21 | 9 | 3 | 9 | 26:25 | 1 | 30 |
| 16 |
|
Estudiantes II | 21 | 6 | 9 | 6 | 19:20 | -1 | 27 |
| 17 |
|
Arsenal de Sarandí II | 21 | 6 | 8 | 7 | 21:21 | 0 | 26 |
| 18 |
|
Unión de Santa Fe II | 21 | 6 | 8 | 7 | 19:21 | -2 | 26 |
| 19 |
|
Colón de Santa Fe II | 21 | 6 | 8 | 7 | 27:31 | -4 | 26 |
| 20 |
|
Godoy Cruz II | 21 | 6 | 7 | 8 | 26:28 | -2 | 25 |
| 21 |
|
Central Córdoba SdE II | 21 | 7 | 4 | 10 | 21:32 | -11 | 25 |
| 22 |
|
Platense II | 21 | 4 | 11 | 6 | 19:22 | -3 | 23 |
| 23 |
|
Atlético Tucumán II | 21 | 6 | 4 | 11 | 28:35 | -7 | 22 |
| 24 |
|
Racing Club II | 21 | 5 | 6 | 10 | 27:27 | 0 | 21 |
| 25 |
|
Sarmiento de Junín II | 21 | 6 | 3 | 12 | 16:34 | -18 | 21 |
| 26 |
|
Patronato de Paraná II | 21 | 5 | 4 | 12 | 17:35 | -18 | 19 |
| 27 |
|
Barracas Central II | 21 | 6 | 1 | 14 | 15:38 | -23 | 19 |
| 28 |
|
Aldosivi II | 21 | 5 | 3 | 13 | 26:44 | -18 | 18 |
