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| 29.08.2021 | 20:00 | Juventud Unida de Gualeguaychú | - | Gimnasia y Esgrima (CdU) | 4:2 (2:0) | |
| 20:30 | Gimnasia y Tiro de Salta | - | Racing de Córdoba | 0:0 (0:0) | ||
| 20:30 | Sarmiento de Resistencia | - | Chaco For Ever | 1:1 (1:0) | ||
| 21:00 | Defensores Belgrano (VR) | - | Unión de Sunchales | 0:0 (0:0) | ||
| 30.08.2021 | 21:00 | Boca Unidos | - | Douglas Haig | 1:0 (1:0) | |
| 01.09.2021 | 20:30 | Defensores de Pronunciamiento | - | Crucero del Norte | 1:1 (1:1) | |
| 21:00 | Belgrano de San Francisco | - | Central Norte | 0:2 (0:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 19 | 11 | 6 | 2 | 26:6 | 20 | 39 |
| 2 |
|
Gimnasia y Tiro de Salta | 19 | 11 | 6 | 2 | 24:12 | 12 | 39 |
| 3 |
|
Central Norte | 19 | 7 | 10 | 2 | 27:17 | 10 | 31 |
| 4 |
|
Chaco For Ever | 19 | 7 | 8 | 4 | 24:17 | 7 | 29 |
| 5 |
|
Sportivo Las Parejas | 18 | 6 | 6 | 6 | 19:18 | 1 | 24 |
| 6 |
|
Boca Unidos | 19 | 5 | 9 | 5 | 26:26 | 0 | 24 |
| 7 |
|
Sarmiento de Resistencia | 19 | 6 | 6 | 7 | 25:27 | -2 | 24 |
| 8 |
|
Defensores de Pronunciamiento | 18 | 5 | 8 | 5 | 20:20 | 0 | 23 |
| 9 |
|
Unión de Sunchales | 19 | 5 | 8 | 6 | 19:21 | -2 | 23 |
| 10 |
|
Juventud Unida de Gualeguaychú | 19 | 5 | 7 | 7 | 20:24 | -4 | 22 |
| 11 |
|
Defensores Belgrano (VR) | 18 | 6 | 3 | 9 | 22:28 | -6 | 21 |
| 12 |
|
Gimnasia y Esgrima (CdU) | 18 | 6 | 3 | 9 | 16:25 | -9 | 21 |
| 13 |
|
Belgrano de San Francisco | 19 | 3 | 9 | 7 | 19:26 | -7 | 18 |
| 14 |
|
Crucero del Norte | 19 | 4 | 5 | 10 | 14:29 | -15 | 17 |
| 15 |
|
Douglas Haig | 18 | 4 | 4 | 10 | 8:13 | -5 | 16 |
| Play-offs | |
| Volgende Ronde |
