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| 10.09.2021 | 20:00 | Juventud Unida de Gualeguaychú | - | Sportivo Las Parejas | 1:0 (0:0) | |
| 20:30 | Gimnasia y Tiro de Salta | - | Douglas Haig | 4:2 (3:2) | ||
| 20:30 | Defensores de Pronunciamiento | - | Chaco For Ever | 0:2 (0:2) | ||
| 21:00 | Defensores Belgrano (VR) | - | Central Norte | 2:0 (1:0) | ||
| 11.09.2021 | 00:00 | Sarmiento de Resistencia | - | Gimnasia y Esgrima (CdU) | 0:0 (0:0) | |
| 01:30 | Belgrano de San Francisco | - | Racing de Córdoba | 1:1 (1:1) | ||
| 01:30 | Unión de Sunchales | - | Crucero del Norte | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Gimnasia y Tiro de Salta | 21 | 13 | 6 | 2 | 29:14 | 15 | 45 |
| 2 |
|
Racing de Córdoba | 21 | 12 | 7 | 2 | 30:9 | 21 | 43 |
| 3 |
|
Chaco For Ever | 21 | 9 | 8 | 4 | 28:17 | 11 | 35 |
| 4 |
|
Central Norte | 21 | 8 | 10 | 3 | 29:19 | 10 | 34 |
| 5 |
|
Juventud Unida de Gualeguaychú | 21 | 7 | 7 | 7 | 22:24 | -2 | 28 |
| 6 |
|
Unión de Sunchales | 20 | 6 | 8 | 6 | 20:21 | -1 | 26 |
| 7 |
|
Boca Unidos | 20 | 5 | 10 | 5 | 27:27 | 0 | 25 |
| 8 |
|
Sportivo Las Parejas | 20 | 6 | 7 | 7 | 20:20 | 0 | 25 |
| 9 |
|
Sarmiento de Resistencia | 21 | 6 | 7 | 8 | 27:30 | -3 | 25 |
| 10 |
|
Defensores Belgrano (VR) | 20 | 7 | 4 | 9 | 25:29 | -4 | 25 |
| 11 |
|
Defensores de Pronunciamiento | 20 | 5 | 8 | 7 | 20:24 | -4 | 23 |
| 12 |
|
Gimnasia y Esgrima (CdU) | 20 | 6 | 4 | 10 | 16:26 | -10 | 22 |
| 13 |
|
Belgrano de San Francisco | 21 | 3 | 10 | 8 | 20:29 | -9 | 19 |
| 14 |
|
Crucero del Norte | 21 | 4 | 6 | 11 | 15:31 | -16 | 18 |
| 15 |
|
Douglas Haig | 20 | 4 | 4 | 12 | 10:18 | -8 | 16 |
| Play-offs | |
| Volgende Ronde |
