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| 30.10.2010 | 20:00 | KV Oostende | - | RFC Tournai | 2:1 (2:0) | |
| 20:00 | FC Brussels | - | KVK Tienen | 1:2 (0:2) | ||
| 20:00 | FCV Dender EH | - | RAEC Mons | 1:0 (0:0) | ||
| 20:00 | AFC Tubize | - | Rupel Boom FC | 3:1 (0:1) | ||
| 31.10.2010 | 15:00 | RBD Borinage | - | Royal Antwerp FC | 3:0 (1:0) | |
| 15:00 | KSK Heist | - | Lommel United | 1:2 (1:1) | ||
| 15:00 | CS Visé | - | KV Turnhout | 3:1 (2:1) | ||
| 15:00 | Oud-Heverlee Leuven | - | KSV Roeselare | 3:0 (1:0) | ||
| 19:00 | Standaard Wetteren | - | Waasland-Beveren | 1:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KV Oostende | 12 | 9 | 0 | 3 | 19:15 | 4 | 27 |
| 2 |
|
Waasland-Beveren | 12 | 7 | 4 | 1 | 20:6 | 14 | 25 |
| 3 |
|
Oud-Heverlee Leuven | 12 | 7 | 3 | 2 | 28:15 | 13 | 24 |
| 4 |
|
Lommel United | 12 | 7 | 2 | 3 | 28:15 | 13 | 23 |
| 5 |
|
FCV Dender EH | 12 | 7 | 2 | 3 | 23:12 | 11 | 23 |
| 6 |
|
RAEC Mons | 12 | 7 | 2 | 3 | 23:13 | 10 | 23 |
| 7 |
|
CS Visé | 12 | 6 | 3 | 3 | 20:15 | 5 | 21 |
| 8 |
|
KSK Heist | 12 | 6 | 2 | 4 | 23:20 | 3 | 20 |
| 9 |
|
Standaard Wetteren | 12 | 5 | 3 | 4 | 18:17 | 1 | 18 |
| 10 |
|
KVK Tienen | 12 | 5 | 1 | 6 | 14:20 | -6 | 16 |
| 11 |
|
RBD Borinage | 12 | 4 | 3 | 5 | 16:19 | -3 | 15 |
| 12 |
|
Royal Antwerp FC | 12 | 4 | 3 | 5 | 18:23 | -5 | 15 |
| 13 |
|
Rupel Boom FC | 12 | 4 | 2 | 6 | 13:22 | -9 | 14 |
| 14 |
|
FC Brussels | 12 | 3 | 3 | 6 | 15:15 | 0 | 12 |
| 15 |
|
KSV Roeselare | 12 | 2 | 3 | 7 | 14:24 | -10 | 9 |
| 16 |
|
AFC Tubize | 12 | 2 | 3 | 7 | 14:26 | -12 | 9 |
| 17 |
|
KV Turnhout | 12 | 1 | 2 | 9 | 9:24 | -15 | 5 |
| 18 |
|
RFC Tournai | 12 | 0 | 3 | 9 | 13:27 | -14 | 3 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
