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| U | Monarcas Morelia | - | CF Monterrey | 1:3 (0:2) | ||
| R | CF Monterrey | - | Monarcas Morelia | 4:1 (1:0) | ||
| U: 07.03.2012 04:00 | R: 14.03.2012 03:00 | Winnaars: CF Monterrey | ||||
| U | Toronto FC | - | Los Angeles Galaxy | 2:2 (2:1) | ||
| R | Los Angeles Galaxy | - | Toronto FC | 1:2 (0:1) | ||
| U: 08.03.2012 02:00 | R: 15.03.2012 03:00 | Winnaars: Toronto FC | ||||
| U | Seattle Sounders | - | Santos Laguna | 2:1 (1:0) | ||
| R | Santos Laguna | - | Seattle Sounders | 6:1 (2:1) | ||
| U: 08.03.2012 04:00 | R: 15.03.2012 01:00 | Winnaars: Santos Laguna | ||||
| U | Isidro Metapán | - | Pumas UNAM | 2:1 (1:0) | ||
| R | Pumas UNAM | - | Isidro Metapán | 8:0 (3:0) | ||
| U: 09.03.2012 02:00 | R: 16.03.2012 03:00 | Winnaars: Pumas UNAM | ||||
