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| U | Bolívar | - | Santos FC | 2:1 (1:1) | ||
| R | Santos FC | - | Bolívar | 8:0 (5:0) | ||
| U: 26.04.2012 02:50 | R: 11.05.2012 00:30 | Winnaars: Santos FC | ||||
| U | Internacional | - | Fluminense RJ | 0:0 (0:0) | ||
| R | Fluminense RJ | - | Internacional | 2:1 (2:1) | ||
| U: 26.04.2012 02:50 | R: 11.05.2012 03:00 | Winnaars: Fluminense RJ | ||||
| U | Atlético Nacional | - | Vélez Sarsfield | 0:1 (0:1) | ||
| R | Vélez Sarsfield | - | Atlético Nacional | 1:1 (0:0) | ||
| U: 02.05.2012 02:15 | R: 09.05.2012 01:00 | Winnaars: Vélez Sarsfield | ||||
| U | Cruz Azul | - | Libertad | 1:1 (1:0) | ||
| R | Libertad | - | Cruz Azul | 2:0 (1:0) | ||
| U: 02.05.2012 04:30 | R: 09.05.2012 03:30 | Winnaars: Libertad | ||||
| U | Boca Juniors | - | Unión Española | 2:1 (1:0) | ||
| R | Unión Española | - | Boca Juniors | 2:3 (0:1) | ||
| U: 03.05.2012 00:30 | R: 10.05.2012 00:30 | Winnaars: Boca Juniors | ||||
| U | Emelec | - | Corinthians SP | 0:0 (0:0) | ||
| R | Corinthians SP | - | Emelec | 3:0 (1:0) | ||
| U: 03.05.2012 02:50 | R: 10.05.2012 03:00 | Winnaars: Corinthians SP | ||||
| U | Vasco da Gama - RJ | - | Lanús | 2:1 (2:0) | ||
| R | Lanús | - | Vasco da Gama - RJ | 4:5 (0:1, 2:1, 2:1) d.p. | ||
| U: 03.05.2012 02:50 | R: 10.05.2012 03:00 | Winnaars: Vasco da Gama - RJ | ||||
| U | Deportivo Quito | - | Universidad de Chile | 4:1 (2:1) | ||
| R | Universidad de Chile | - | Deportivo Quito | 6:0 (3:0) | ||
| U: 04.05.2012 02:15 | R: 11.05.2012 03:00 | Winnaars: Universidad de Chile | ||||
