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| U | São Paulo FC | - | Atlético Mineiro | 1:0 (0:0) | ||
| R | Atlético Mineiro | - | São Paulo FC | 2:1 (2:1) | ||
| U: 12.05.2016 02:45 | R: 19.05.2016 02:45 | Winnaars: São Paulo FC | ||||
| U | Nacional | - | Boca Juniors | 1:1 (0:0) | ||
| R | Boca Juniors | - | Nacional | 4:3 (0:1, 1:1) d.p. | ||
| U: 13.05.2016 00:30 | R: 20.05.2016 01:15 | Winnaars: Boca Juniors | ||||
| U | Rosario Central | - | Atlético Nacional | 1:0 (1:0) | ||
| R | Atlético Nacional | - | Rosario Central | 3:1 (1:1) | ||
| U: 13.05.2016 02:45 | R: 20.05.2016 03:45 | Winnaars: Atlético Nacional | ||||
| U | Independiente del Valle | - | Pumas UNAM | 2:1 (1:0) | ||
| R | Pumas UNAM | - | Independiente del Valle | 3:5 (2:0, 2:1) d.p. | ||
| U: 18.05.2016 02:45 | R: 25.05.2016 02:45 | Winnaars: Independiente del Valle | ||||
