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| U | Santa Fe | - | Deportivo Cali | 1:1 (1:1) | ||
| R | Deportivo Cali | - | Santa Fe | 1:2 (0:2) | ||
| U: 24.10.2018 02:45 | R: 31.10.2018 01:45 | Winnaars: Santa Fe | ||||
| U | Fluminense RJ | - | Nacional | 1:1 (1:0) | ||
| R | Nacional | - | Fluminense RJ | 0:1 (0:0) | ||
| U: 25.10.2018 00:30 | R: 31.10.2018 23:30 | Winnaars: Fluminense RJ | ||||
| U | Bahia - BA | - | Athletico Paranaense | 0:1 (0:0) | ||
| R | Athletico Paranaense | - | Bahia - BA | 4:1 (0:1, 0:1) d.p. | ||
| U: 25.10.2018 02:45 | R: 01.11.2018 01:45 | Winnaars: Athletico Paranaense | ||||
| U | Atlético Junior | - | Defensa y Justicia | 2:0 (0:0) | ||
| R | Defensa y Justicia | - | Atlético Junior | 3:1 (2:0) | ||
| U: 26.10.2018 02:45 | R: 02.11.2018 01:45 | Winnaars: Atlético Junior | ||||
