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| 19.02.2021 | 16:00 | FK Jablonec | - | FK Mladá Boleslav | 1:1 (1:1) | |
| 20.02.2021 | 14:00 | FK Pardubice | - | Baník Ostrava | 3:2 (1:0) | |
| 14:00 | 1. FK Příbram | - | 1. FC Slovácko | 1:4 (0:2) | ||
| 14:00 | Sigma Olomouc | - | Zbrojovka Brno | 1:0 (0:0) | ||
| 16:30 | FC Fastav Zlín | - | Sparta Praag | 0:3 (0:2) | ||
| 21.02.2021 | 14:00 | Dynamo České Budějovice | - | SFC Opava | 0:1 (0:0) | |
| 14:00 | MFK Karviná | - | Slovan Liberec | 1:1 (0:0) | ||
| 14:00 | Viktoria Plzeň | - | Bohemians Praha 1905 | 3:1 (1:0) | ||
| 16:30 | FK Teplice | - | Slavia Praag | 1:1 (0:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slavia Praag | 20 | 16 | 4 | 0 | 58:12 | 46 | 52 |
| 2 |
|
Sparta Praag | 20 | 14 | 2 | 4 | 43:24 | 19 | 44 |
| 3 |
|
1. FC Slovácko | 20 | 12 | 4 | 4 | 39:18 | 21 | 40 |
| 4 |
|
FK Jablonec | 20 | 11 | 3 | 6 | 35:25 | 10 | 36 |
| 5 |
|
Slovan Liberec | 20 | 9 | 6 | 5 | 28:18 | 10 | 33 |
| 6 |
|
Viktoria Plzeň | 20 | 9 | 4 | 7 | 37:26 | 11 | 31 |
| 7 |
|
FK Pardubice | 20 | 9 | 4 | 7 | 20:24 | -4 | 31 |
| 8 |
|
Sigma Olomouc | 20 | 7 | 9 | 4 | 29:23 | 6 | 30 |
| 9 |
|
Baník Ostrava | 20 | 8 | 5 | 7 | 25:20 | 5 | 29 |
| 10 |
|
Dynamo České Budějovice | 20 | 7 | 8 | 5 | 24:24 | 0 | 29 |
| 11 |
|
MFK Karviná | 20 | 6 | 7 | 7 | 24:31 | -7 | 25 |
| 12 |
|
Bohemians Praha 1905 | 20 | 6 | 5 | 9 | 22:26 | -4 | 23 |
| 13 |
|
FC Fastav Zlín | 20 | 6 | 4 | 10 | 20:29 | -9 | 22 |
| 14 |
|
FK Teplice | 20 | 5 | 3 | 12 | 19:41 | -22 | 18 |
| 15 |
|
Zbrojovka Brno | 20 | 3 | 5 | 12 | 16:34 | -18 | 14 |
| 16 |
|
FK Mladá Boleslav | 20 | 2 | 7 | 11 | 22:36 | -14 | 13 |
| 17 |
|
1. FK Příbram | 20 | 2 | 6 | 12 | 16:40 | -24 | 12 |
| 18 |
|
SFC Opava | 20 | 2 | 6 | 12 | 13:39 | -26 | 12 |
| Champions League Kwali. | |
| Europa League Kwali. | |
| Degradatie |
