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| 07.05.2021 | 18:00 | FK Jablonec | - | FK Teplice | 4:1 (2:0) | |
| 08.05.2021 | 15:00 | FC Fastav Zlín | - | SFC Opava | 1:1 (0:1) | |
| 17:00 | Zbrojovka Brno | - | FK Mladá Boleslav | 2:3 (0:2) | ||
| 17:00 | Viktoria Plzeň | - | 1. FK Příbram | 3:3 (1:2) | ||
| 19:30 | Bohemians Praha 1905 | - | Slovan Liberec | 3:0 (0:0) | ||
| 09.05.2021 | 15:00 | Dynamo České Budějovice | - | FK Pardubice | 2:0 (1:0) | |
| 15:00 | MFK Karviná | - | 1. FC Slovácko | 0:2 (0:1) | ||
| 17:00 | Sigma Olomouc | - | Slavia Praag | 0:1 (0:0) | ||
| 19:30 | Sparta Praag | - | Baník Ostrava | 3:1 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slavia Praag | 31 | 25 | 6 | 0 | 81:17 | 64 | 81 |
| 2 |
|
Sparta Praag | 31 | 20 | 5 | 6 | 69:37 | 32 | 65 |
| 3 |
|
FK Jablonec | 31 | 20 | 5 | 6 | 57:31 | 26 | 65 |
| 4 |
|
1. FC Slovácko | 31 | 17 | 5 | 9 | 54:32 | 22 | 56 |
| 5 |
|
Viktoria Plzeň | 31 | 15 | 7 | 9 | 53:41 | 12 | 52 |
| 6 |
|
Slovan Liberec | 31 | 14 | 8 | 9 | 42:29 | 13 | 50 |
| 7 |
|
FK Pardubice | 31 | 13 | 7 | 11 | 37:41 | -4 | 46 |
| 8 |
|
Baník Ostrava | 31 | 12 | 9 | 10 | 43:31 | 12 | 45 |
| 9 |
|
Bohemians Praha 1905 | 31 | 10 | 12 | 9 | 37:31 | 6 | 42 |
| 10 |
|
Sigma Olomouc | 31 | 9 | 12 | 10 | 36:35 | 1 | 39 |
| 11 |
|
Dynamo České Budějovice | 31 | 9 | 11 | 11 | 32:42 | -10 | 38 |
| 12 |
|
MFK Karviná | 31 | 8 | 10 | 13 | 33:47 | -14 | 34 |
| 13 |
|
FK Mladá Boleslav | 31 | 8 | 9 | 14 | 39:48 | -9 | 33 |
| 14 |
|
FC Fastav Zlín | 31 | 8 | 7 | 16 | 28:44 | -16 | 31 |
| 15 |
|
FK Teplice | 31 | 6 | 8 | 17 | 30:62 | -32 | 26 |
| 16 |
|
Zbrojovka Brno | 31 | 4 | 10 | 17 | 27:49 | -22 | 22 |
| 17 |
|
1. FK Příbram | 31 | 4 | 9 | 18 | 23:62 | -39 | 21 |
| 18 |
|
SFC Opava | 31 | 3 | 8 | 20 | 20:62 | -42 | 17 |
| Champions League Kwali. | |
| Europa League Kwali. | |
| Degradatie |
