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| 11.12.2021 | 15:00 | FK Pardubice | - | Baník Ostrava | 0:3 (0:2) | |
| 15:00 | FC Hradec Králové | - | 1. FC Slovácko | 2:2 (0:1) | ||
| 15:00 | FC Fastav Zlín | - | MFK Karviná | 2:1 (1:1) | ||
| 18:00 | Viktoria Plzeň | - | Slovan Liberec | 2:0 (2:0) | ||
| 12.12.2021 | 15:00 | Slavia Praag | - | FK Mladá Boleslav | 2:0 (2:0) | |
| 15:00 | FK Jablonec | - | FK Teplice | 0:2 (0:1) | ||
| 15:00 | Dynamo České Budějovice | - | Sigma Olomouc | 2:1 (1:0) | ||
| 18:00 | Sparta Praag | - | Bohemians Praha 1905 | 5:1 (4:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slavia Praag | 18 | 15 | 2 | 1 | 48:11 | 37 | 47 |
| 2 |
|
Viktoria Plzeň | 18 | 14 | 2 | 2 | 35:13 | 22 | 44 |
| 3 |
|
Sparta Praag | 18 | 13 | 3 | 2 | 45:22 | 23 | 42 |
| 4 |
|
1. FC Slovácko | 18 | 11 | 3 | 4 | 36:21 | 15 | 36 |
| 5 |
|
Baník Ostrava | 18 | 10 | 5 | 3 | 38:22 | 16 | 35 |
| 6 |
|
FC Hradec Králové | 18 | 6 | 7 | 5 | 24:25 | -1 | 25 |
| 7 |
|
Dynamo České Budějovice | 18 | 7 | 3 | 8 | 26:30 | -4 | 24 |
| 8 |
|
FK Mladá Boleslav | 18 | 7 | 2 | 9 | 28:28 | 0 | 23 |
| 9 |
|
Slovan Liberec | 18 | 7 | 2 | 9 | 17:25 | -8 | 23 |
| 10 |
|
Sigma Olomouc | 18 | 5 | 6 | 7 | 30:27 | 3 | 21 |
| 11 |
|
FC Fastav Zlín | 18 | 5 | 3 | 10 | 22:36 | -14 | 18 |
| 12 |
|
Bohemians Praha 1905 | 18 | 5 | 3 | 10 | 26:42 | -16 | 18 |
| 13 |
|
FK Jablonec | 18 | 3 | 7 | 8 | 13:32 | -19 | 16 |
| 14 |
|
FK Pardubice | 18 | 3 | 5 | 10 | 22:40 | -18 | 14 |
| 15 |
|
FK Teplice | 18 | 3 | 2 | 13 | 19:36 | -17 | 11 |
| 16 |
|
MFK Karviná | 18 | 0 | 5 | 13 | 16:35 | -19 | 5 |
| Play-offs | |
| Play-offs | |
| Promotie en degradatie |
