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| U | RCD Mallorca | - | Getafe CF | 1:2 (0:0) | ||
| R | Getafe CF | - | RCD Mallorca | 0:1 (0:1) | ||
| U: 20.01.2010 20:00 | R: 28.01.2010 20:00 | Winnaars: Getafe CF | ||||
| U | Deportivo La Coruña | - | Sevilla FC | 0:3 (0:1) | ||
| R | Sevilla FC | - | Deportivo La Coruña | 0:1 (0:1) | ||
| U: 20.01.2010 22:00 | R: 27.01.2010 22:00 | Winnaars: Sevilla FC | ||||
| U | Racing Santander | - | CA Osasuna | 2:1 (0:0) | ||
| R | CA Osasuna | - | Racing Santander | 0:3 (0:2) | ||
| U: 21.01.2010 20:00 | R: 27.01.2010 20:00 | Winnaars: Racing Santander | ||||
| U | Atlético Madrid | - | Celta de Vigo | 1:1 (1:1) | ||
| R | Celta de Vigo | - | Atlético Madrid | 0:1 (0:1) | ||
| U: 21.01.2010 22:00 | R: 28.01.2010 22:00 | Winnaars: Atlético Madrid | ||||
