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| 04.02.2022 | 21:00 | Burgos CF | - | AD Alcorcón | 3:1 (2:1) | |
| 21:00 | UD Almería | - | UD Ibiza | 2:0 (0:0) | ||
| 05.02.2022 | 16:00 | Real Sociedad B | - | CD Lugo | 1:1 (0:1) | |
| 18:15 | Real Zaragoza | - | Málaga CF | 1:1 (0:1) | ||
| 20:30 | Girona FC | - | SD Ponferradina | 3:0 (1:0) | ||
| 20:30 | Sporting Gijón | - | SD Eibar | 0:1 (0:1) | ||
| 06.02.2022 | 14:00 | SD Amorebieta | - | Real Oviedo | 1:1 (1:1) | |
| 14:00 | CF Fuenlabrada | - | Real Valladolid | 0:0 (0:0) | ||
| 18:15 | FC Cartagena | - | UD Las Palmas | 0:2 (0:2) | ||
| 18:15 | SD Huesca | - | CD Mirandés | 4:0 (0:0) | ||
| 21:00 | CD Tenerife | - | CD Leganés | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SD Eibar | 26 | 15 | 7 | 4 | 40:28 | 12 | 52 |
| 2 |
|
UD Almería | 26 | 15 | 4 | 7 | 41:21 | 20 | 49 |
| 3 |
|
Real Valladolid | 26 | 14 | 6 | 6 | 36:24 | 12 | 48 |
| 4 |
|
CD Tenerife | 26 | 13 | 7 | 6 | 35:19 | 16 | 46 |
| 5 |
|
SD Ponferradina | 26 | 11 | 8 | 7 | 31:26 | 5 | 41 |
| 6 |
|
Girona FC | 26 | 12 | 5 | 9 | 36:28 | 8 | 41 |
| 7 |
|
UD Las Palmas | 26 | 10 | 9 | 7 | 34:30 | 4 | 39 |
| 8 |
|
FC Cartagena | 26 | 12 | 3 | 11 | 33:34 | -1 | 39 |
| 9 |
|
Real Oviedo | 26 | 8 | 13 | 5 | 29:25 | 4 | 37 |
| 10 |
|
UD Ibiza | 26 | 8 | 11 | 7 | 34:30 | 4 | 35 |
| 11 |
|
CD Lugo | 26 | 7 | 14 | 5 | 32:29 | 3 | 35 |
| 12 |
|
Burgos CF | 26 | 10 | 5 | 11 | 30:26 | 4 | 35 |
| 13 |
|
SD Huesca | 26 | 8 | 9 | 9 | 31:25 | 6 | 33 |
| 14 |
|
Sporting Gijón | 26 | 8 | 8 | 10 | 26:30 | -4 | 32 |
| 15 |
|
Málaga CF | 26 | 8 | 8 | 10 | 24:39 | -15 | 32 |
| 16 |
|
CD Leganés | 26 | 7 | 9 | 10 | 26:30 | -4 | 30 |
| 17 |
|
CD Mirandés | 26 | 8 | 6 | 12 | 34:40 | -6 | 30 |
| 18 |
|
Real Zaragoza | 26 | 5 | 15 | 6 | 20:26 | -6 | 30 |
| 19 |
|
SD Amorebieta | 26 | 4 | 13 | 9 | 30:37 | -7 | 25 |
| 20 |
|
CF Fuenlabrada | 26 | 4 | 12 | 10 | 20:31 | -11 | 24 |
| 21 |
|
Real Sociedad B | 26 | 4 | 8 | 14 | 21:34 | -13 | 20 |
| 22 |
|
AD Alcorcón | 26 | 2 | 6 | 18 | 19:50 | -31 | 12 |
| Promotie | |
| Play-offs | |
| Degradatie |
