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| U | Deportivo Toluca | - | Cruz Azul | 2:1 (2:0) | ||
| R | Cruz Azul | - | Deportivo Toluca | 1:1 (0:1) | ||
| U: 03.05.2006 22:00 | R: 07.05.2006 00:00 | Winnaars: Deportivo Toluca | ||||
| U | Club San Luis | - | Atlante | 1:0 (0:0) | ||
| R | Atlante | - | Club San Luis | 0:0 (0:0) | ||
| U: 04.05.2006 03:30 | R: 07.05.2006 02:00 | Winnaars: Club San Luis | ||||
| U | Monarcas Morelia | - | CF Pachuca | 2:1 (1:1) | ||
| R | CF Pachuca | - | Monarcas Morelia | 3:1 (2:0) | ||
| U: 05.05.2006 02:00 | R: 08.05.2006 00:00 | Winnaars: CF Pachuca | ||||
| U | Deportivo Guadalajara | - | Jaguares Chiapas | 2:3 (1:1) | ||
| R | Jaguares Chiapas | - | Deportivo Guadalajara | 2:4 (1:2) | ||
| U: 05.05.2006 03:45 | R: 07.05.2006 22:00 | Winnaars: Deportivo Guadalajara | ||||
