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| U | Jaguares Chiapas | - | Cruz Azul | 1:0 (0:0) | ||
| R | Cruz Azul | - | Jaguares Chiapas | 2:1 (0:0) | ||
| U: 15.05.2008 02:00 | R: 18.05.2008 00:00 | Winnaars: Jaguares Chiapas | ||||
| U | CF Monterrey | - | Deportivo Guadalajara | 4:1 (2:1) | ||
| R | Deportivo Guadalajara | - | CF Monterrey | 4:4 (2:2) | ||
| U: 15.05.2008 04:00 | R: 18.05.2008 03:00 | Winnaars: CF Monterrey | ||||
| U | Deportivo Toluca | - | Club San Luis | 1:1 (0:1) | ||
| R | Club San Luis | - | Deportivo Toluca | 0:0 (0:0) | ||
| U: 16.05.2008 02:00 | R: 18.05.2008 19:00 | Winnaars: Club San Luis | ||||
| U | Club Necaxa | - | Santos Laguna | 1:2 (1:1) | ||
| R | Santos Laguna | - | Club Necaxa | 1:1 (0:0) | ||
| U: 16.05.2008 04:00 | R: 19.05.2008 00:00 | Winnaars: Santos Laguna | ||||
