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| U | CF Pachuca | - | CF Monterrey | 1:0 (1:0) | ||
| R | CF Monterrey | - | CF Pachuca | 1:2 (1:0) | ||
| U: 02.05.2010 00:00 | R: 09.05.2010 01:00 | Winnaars: CF Pachuca | ||||
| U | Monarcas Morelia | - | Deportivo Guadalajara | 4:2 (1:2) | ||
| R | Deportivo Guadalajara | - | Monarcas Morelia | 0:1 (0:0) | ||
| U: 02.05.2010 02:00 | R: 09.05.2010 03:00 | Winnaars: Monarcas Morelia | ||||
| U | Santos Laguna | - | Pumas UNAM | 2:0 (1:0) | ||
| R | Pumas UNAM | - | Santos Laguna | 1:0 (0:0) | ||
| U: 03.05.2010 02:00 | R: 10.05.2010 00:00 | Winnaars: Santos Laguna | ||||
| U | CF América | - | Deportivo Toluca | 2:2 (2:2) | ||
| R | Deportivo Toluca | - | CF América | 2:0 (1:0) | ||
| U: 03.05.2010 04:00 | R: 09.05.2010 19:00 | Winnaars: Deportivo Toluca | ||||
