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| 19.11.2010 | 18:00 | FK Senica | - | MŠK Žilina | 2:1 (0:0) | |
| 20.11.2010 | 15:30 | MFK Dubnica | - | Zlaté Moravce | 0:4 (0:2) | |
| 15:30 | 1. FC Tatran Prešov | - | FC DAC 1904 | 1:0 (0:0) | ||
| 15:30 | MFK Ružomberok | - | Slovan Bratislava | 0:0 (0:0) | ||
| 15:30 | FC Nitra | - | FK Dukla Banská Bystrica | 0:2 (0:2) | ||
| 17:30 | Spartak Trnava | - | MFK Košice | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MŠK Žilina | 17 | 10 | 6 | 1 | 37:15 | 22 | 36 |
| 2 |
|
FK Senica | 17 | 9 | 3 | 5 | 20:17 | 3 | 30 |
| 3 |
|
Spartak Trnava | 17 | 7 | 7 | 3 | 21:8 | 13 | 28 |
| 4 |
|
FK Dukla Banská Bystrica | 17 | 7 | 6 | 4 | 22:12 | 10 | 27 |
| 5 |
|
Slovan Bratislava | 17 | 6 | 6 | 5 | 26:15 | 11 | 24 |
| 6 |
|
Zlaté Moravce | 17 | 6 | 6 | 5 | 19:18 | 1 | 24 |
| 7 |
|
FC DAC 1904 | 17 | 6 | 5 | 6 | 16:16 | 0 | 23 |
| 8 |
|
MFK Ružomberok | 17 | 5 | 5 | 7 | 14:21 | -7 | 20 |
| 9 |
|
FC Nitra | 17 | 5 | 4 | 8 | 13:25 | -12 | 19 |
| 10 |
|
1. FC Tatran Prešov | 17 | 4 | 5 | 8 | 12:18 | -6 | 17 |
| 11 |
|
MFK Košice | 17 | 3 | 5 | 9 | 14:27 | -13 | 14 |
| 12 |
|
MFK Dubnica | 17 | 4 | 2 | 11 | 13:35 | -22 | 14 |
| Champions League Kwali. | |
| Europa League | |
| Degradatie |
