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| U | Chicago Fire | - | D.C. United | 0:0 (0:0) | ||
| R | D.C. United | - | Chicago Fire | 0:4 (0:3) | ||
| U: 22.10.2005 03:00 | R: 30.10.2005 22:30 | Winnaars: Chicago Fire | ||||
| U | MetroStars | - | New England Revolution | 1:0 (1:0) | ||
| R | New England Revolution | - | MetroStars | 3:1 (0:0) | ||
| U: 23.10.2005 01:00 | R: 30.10.2005 02:00 | Winnaars: New England Revolution | ||||
| U | Colorado Rapids | - | FC Dallas | 0:0 (0:0) | ||
| R | FC Dallas | - | Colorado Rapids | 4:5 (0:1, 1:1, 2:2) d.p. | ||
| U: 23.10.2005 03:00 | R: 30.10.2005 02:30 | Winnaars: Colorado Rapids | ||||
| U | Los Angeles Galaxy | - | San Jose Earthquakes | 3:1 (2:0) | ||
| R | San Jose Earthquakes | - | Los Angeles Galaxy | 1:1 (1:0) | ||
| U: 23.10.2005 21:00 | R: 30.10.2005 04:00 | Winnaars: Los Angeles Galaxy | ||||
