| 2. Ronde | 23.07.2021 | Defensa y Justicia II | - | Godoy Cruz II | 2:1 | ||||
| 3. Ronde | 27.07.2021 | Godoy Cruz II | - | Atlético Tucumán II | 2:2 | ||||
| 5. Ronde | 06.08.2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 6. Ronde | 13.08.2021 | Lanús II | - | Godoy Cruz II | 5:1 | ||||
| 7. Ronde | 20.08.2021 | Godoy Cruz II | - | Huracán II | 2:1 | ||||
| 10. Ronde | 05.09.2021 | Godoy Cruz II | - | Gimnasia de La Plata II | 3:0 | ||||
| 11. Ronde | 13.09.2021 | Aldosivi II | - | Godoy Cruz II | 1:2 | ||||
| 12. Ronde | 17.09.2021 | Godoy Cruz II | - | Sarmiento de Junín II | 0:0 | ||||
| 13. Ronde | 23.09.2021 | Independiente II | - | Godoy Cruz II | 0:0 | ||||
| 17. Ronde | 19.10.2021 | Boca Juniors II | - | Godoy Cruz II | 6:0 | ||||
| 20. Ronde | 05.11.2021 | Godoy Cruz II | - | Talleres de Córdoba II | 1:1 | ||||
| 9. Ronde | 11.11.2021 | Vélez Sarsfield II | - | Godoy Cruz II | 3:0 | ||||
| 24. Ronde | 03.12.2021 | Godoy Cruz II | - | Platense II | 0:2 |
Argentinië