| 2. Ronde | 25.07.2021 | River Plate | - | Unión de Santa Fe | 4:0 | ||||
| 3. Ronde | 29.07.2021 | Lanús | - | River Plate | 0:3 | ||||
| 4. Ronde | 01.08.2021 | River Plate | - | Huracán | 1:1 | ||||
| 5. Ronde | 08.08.2021 | Godoy Cruz | - | River Plate | 2:1 |  |
|||
| 6. Ronde | 14.08.2021 | River Plate | - | Vélez Sarsfield | 2:0 | ||||
| 9. Ronde | 31.08.2021 | Sarmiento de Junín | - | River Plate | 1:2 | ||||
| 10. Ronde | 06.09.2021 | River Plate | - | Independiente | 1:1 | ||||
| 11. Ronde | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 12. Ronde | 20.09.2021 | River Plate | - | Arsenal de Sarandí | 1:0 | ||||
| 13. Ronde | 26.09.2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
| 14. Ronde | 03.10.2021 | River Plate | - | Boca Juniors | 2:1 | |
|||
| 15. Ronde | 09.10.2021 | Banfield | - | River Plate | 0:1 | ||||
| 16. Ronde | 18.10.2021 | River Plate | - | San Lorenzo | 3:1 | ||||
| 17. Ronde | 22.10.2021 | Talleres de Córdoba | - | River Plate | 0:2 | ||||
| 18. Ronde | 26.10.2021 | River Plate | - | Argentinos Juniors | 3:0 | ||||
| 19. Ronde | 01.11.2021 | Estudiantes | - | River Plate | 1:1 | ||||
| 20. Ronde | 08.11.2021 | River Plate | - | Patronato de Paraná | 5:0 | ||||
| 25. Ronde | 11.12.2021 | Atlético Tucumán | - | River Plate | 1:1 |
Argentinië
Paraguay