| 1. Ronde | 20.07.2021 | Godoy Cruz | - | Rosario Central | 2:1 | ||||
| 2. Ronde | 25.07.2021 | Rosario Central | - | Vélez Sarsfield | 1:0 |  |
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| 3. Ronde | 29.07.2021 | Gimnasia de La Plata | - | Rosario Central | 1:0 | ||||
| 4. Ronde | 03.08.2021 | Rosario Central | - | Aldosivi | 1:2 |  |
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| 7. Ronde | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 | |
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| 10. Ronde | 05.09.2021 | Rosario Central | - | Boca Juniors | 1:2 | ||||
| 11. Ronde | 15.09.2021 | Banfield | - | Rosario Central | 1:2 |  |
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| 16. Ronde | 15.10.2021 | Rosario Central | - | Patronato de Paraná | 3:2 | |
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| 17. Ronde | 19.10.2021 | Platense | - | Rosario Central | 1:1 | ||||
| 18. Ronde | 24.10.2021 | Rosario Central | - | Racing Club | 2:1 | ||||
| 21. Ronde | 20.11.2021 | Rosario Central | - | Atlético Tucumán | 3:1 | |
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| 22. Ronde | 25.11.2021 | Colón de Santa Fe | - | Rosario Central | 1:4 | |
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| 23. Ronde | 28.11.2021 | Rosario Central | - | River Plate | 2:2 | ||||
| 24. Ronde | 05.12.2021 | Lanús | - | Rosario Central | 2:2 | ||||
| 25. Ronde | 11.12.2021 | Rosario Central | - | Huracán | 1:4 |
Argentinië
Italië