| 4. Ronde | 29.01.2022 | CF Monterrey [] | - | Mazatlán FC [] | 3:2 |  |
|||
| 5. Ronde | 05.02.2022 | Mazatlán FC [] | - | UANL Tigres [] | 1:2 | |
|||
| 6. Ronde | 12.02.2022 | Mazatlán FC [] | - | Club Tijuana [] | 1:3 | ||||
| 7. Ronde | 19.02.2022 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 2:0 | ||||
| 8. Ronde | 26.02.2022 | Mazatlán FC [] | - | Santos Laguna [] | 0:3 | ||||
| 9. Ronde | 05.03.2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
| 10. Ronde | 12.03.2022 | Mazatlán FC [] | - | CF Monterrey [] | 1:3 | ||||
| 11. Ronde | 19.03.2022 | UANL Tigres [] | - | Mazatlán FC [] | 5:0 | ||||
| 12. Ronde | 26.03.2022 | Santos Laguna [] | - | Mazatlán FC [] | 3:2 | ||||
| 14. Ronde | 09.04.2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 1:2 | ||||
| 16. Ronde | 23.04.2022 | Mazatlán FC [] | - | Atlético San Luis [] | 2:0 | |
|||
| 17. Ronde | 30.04.2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 |
Mexico