| 1. Ronde | 16.07.2021 | Godoy Cruz II | - | Rosario Central II | 1:1 | ||||
| 2. Ronde | 23.07.2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 |  |
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| 3. Ronde | 27.07.2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 | ||||
| 4. Ronde | 30.07.2021 | Rosario Central II | - | Aldosivi II | 4:1 | ||||
| 16. Ronde | 13.10.2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 17. Ronde | 18.10.2021 | Platense II | - | Rosario Central II | 0:3 | ||||
| 18. Ronde | 24.10.2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 20. Ronde | 05.11.2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 21. Ronde | 20.11.2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 | ||||
| 22. Ronde | 24.11.2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 | ||||
| 23. Ronde | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 25. Ronde | 10.12.2021 | Rosario Central II | - | Huracán II | 2:0 |
Argentinië